Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490404 | 0.91 | DRD2 (0.58) | HSD11B1DRD2DRD3HTR1AADRA1D | |
| SCHEMBL13919815 | 0.89 | DRD2 (0.60) | HSD11B1DRD2DRD3HTR1AADRA1D | |
| SCHEMBL13919809 | 0.88 | DRD2 (0.57) | HSD11B1DRD2DRD3HTR1AADRA1D | |
| SCHEMBL4487563 | 0.87 | HSD11B1 (0.56) | HSD11B1 | |
| SCHEMBL4479630 | 0.87 | HSD11B1 (0.48) | HSD11B1DRD2DRD3HTR1AADRA1D | |
| SCHEMBL13932980 | 0.86 | HSD11B1 (0.56) | HSD11B1DRD2DRD3 | |
| SCHEMBL13932979 | 0.86 | HSD11B1 (0.56) | HSD11B1DRD2DRD3 | |
| SCHEMBL4481410 | 0.86 | HSD11B1 (0.55) | HSD11B1 | |
| SCHEMBL13932981 | 0.86 | HSD11B1 (0.52) | HSD11B1DRD2DRD3 | |
| SCHEMBL4482583 | 0.85 | HSD11B1 (0.53) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511141-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | claimed |
| US-7511141-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511141-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |