Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486192 | 1.00 | TAAR1 (0.52) | TAAR1ALDH1A1HIF1ATDP1KDM4E | |
| SCHEMBL14042112 | 1.00 | TAAR1 (0.52) | TAAR1ALDH1A1HIF1ATDP1KDM4E | |
| SCHEMBL28827835 | 0.85 | MAPT (0.47) | ALDH1A1TDP1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL28823648 | 0.84 | MEN1 (0.48) | ALDH1A1MAPTRAB9AHTT | |
| SCHEMBL8770926 | 0.84 | L3MBTL1 (0.47) | BLMNFKB1MAPTRAB9ALMNA | |
| SCHEMBL8770907 | 0.84 | MEN1 (0.48) | ALDH1A1MAPTRAB9AHTT | |
| SCHEMBL5468798 | 0.84 | AOC3 (0.57) | ALDH1A1TDP1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL29697542 | 0.84 | L3MBTL1 (0.47) | BLMNFKB1MAPTRAB9ALMNA | |
| SCHEMBL8770971 | 0.84 | HTT (0.59) | ALDH1A1CYP2C9MAPTRAB9AHTT | |
| SCHEMBL6862384 | 0.83 | KCNA5 (0.51) | ALDH1A1KDM4ESMN1; SMN2TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7002008-B2 | Process for the preparation of 1-(4-fluorophenyl)-4(S)-(4-hydroxyphenyl)-azetidin-2-one | FRAMROZE BOMI PATEL | 2006-02-21 | — | — | US | claimed |
| US-7498431-B2 | Process for the preparation of chiral azetidinones | FRAMROZE BOMI PATEL | 2009-03-03 | — | — | US | disclosed |
| US-20070129540-A1 | Process for the preparation of chiral azetidinones | OPUS ORGANICS PVT LIMITED (IN) | 2007-06-07 | — | — | US | disclosed |
| US-7002008-B2 | Process for the preparation of 1-(4-fluorophenyl)-4(S)-(4-hydroxyphenyl)-azetidin-2-one | FRAMROZE BOMI PATEL | 2006-02-21 | — | — | US | disclosed |
| US-20040254369-A1 | Process for the preparation of 1-(4-fluorophenyl)-4(S)-(4-hydroxyphenyl)-azetidin-2-one | FRAMROZE BOMI PATEL (IN) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129540-A1 | Process for the preparation of chiral azetidinones | CYP1B1, ALDH7A1, CYP3A5 | TAAR1 4377/4885ALDH1A1 79/4885HIF1A 4076/4885 |
| US-20040254369-A1 | Process for the preparation of 1-(4-fluorophenyl)-4(S)-(4-hydroxyphenyl)-azetidin-2-one | HPD, PAH, CYP4B1 | TAAR1 3865/4885ALDH1A1 73/4885HIF1A 974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.