Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480374 | 0.89 | ESR1 (0.56) | ESR1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4484338 | 0.84 | NR1H2 (0.50) | ESR1SMN1; SMN2ALDH1A1NR1H2NR1H3 | |
| SCHEMBL4474677 | 0.81 | ESR1 (0.47) | ESR1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4025667 | 0.78 | ESR1 (1.00) | ESR1KMT2AMEN1MAPTESR2 | |
| SCHEMBL4478391 | 0.76 | ESR1 (0.47) | ESR1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4027546 | 0.73 | ESR1 (0.83) | ESR1KMT2AMEN1MAPTESR2 | |
| SCHEMBL29321460 | 0.72 | ESR1 (0.60) | ESR1RBP4NR1H2NR1H3 | |
| SCHEMBL4031688 | 0.71 | ESR1 (1.00) | ESR1ESR2RORC | |
| SCHEMBL6112212 | 0.71 | ESR1 (0.56) | ESR1SMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4493386 | 0.69 | CTNNB1 (0.40) | ESR1LMNASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | claimed |
| US-7598286-B2 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | disclosed |
| WO-2006050006-A2 | ((1H-INDAZOL-3-YL)METHYL) PHENOLS AND (HYDROXYPHENYL)(1H-INDAZOL-3-YL) METHANONES AS LIGANDS OF THE ESTROGEN RECEPTOR | WYETH (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | PTGS1, NOS3, PTGIS | ESR1 890/4885LMNA 2104/4885SMN1; SMN2 2781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.