Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31330402 | 0.85 | HSP90AA1 (0.37) | HTR6GPR119ENPP3ENPP1BUB1 | |
| SCHEMBL1457357 | 0.85 | HSP90AA1 (0.37) | HTR6GPR119ENPP3ENPP1BUB1 | |
| SCHEMBL15077838 | 0.83 | BUB1 (0.34) | HTR6GPR119ENPP3ENPP1BUB1 | |
| SCHEMBL3762275 | 0.83 | ELANE (0.47) | HTR6GPR119L3MBTL1ELANEBRD4 | |
| SCHEMBL24319665 | 0.79 | BUB1 (0.39) | GPR119ENPP3ENPP1BUB1L3MBTL1 | |
| SCHEMBL29128021 | 0.79 | BUB1 (0.39) | HTR6GPR119ENPP3ENPP1BUB1 | |
| SCHEMBL580658 | 0.78 | ENPP3 (0.48) | GPR119ENPP3ENPP1BUB1L3MBTL1 | |
| SCHEMBL138212 | 0.78 | PIK3CA (0.38) | GPR119ENPP3ENPP1BUB1L3MBTL1 | |
| SCHEMBL2792837 | 0.78 | HSP90AA1 (0.39) | ENPP3ENPP1BUB1L3MBTL1ACHE | |
| SCHEMBL31240726 | 0.78 | ENPP3 (0.48) | GPR119ENPP3ENPP1BUB1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-A4 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-1696920-A2 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005062795-A2 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON, INC. (US) | 2005-07-14 | — | — | WO | disclosed |