Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.75 |
| ▸ | CDK2 | P24941 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559036 | 0.91 | GSK3B (0.67) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL4505822 | 0.89 | GSK3B (0.66) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL4503229 | 0.88 | GSK3B (0.64) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL4481921 | 0.88 | GSK3B (0.63) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL4483246 | 0.87 | GSK3B (0.69) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL4503186 | 0.87 | GSK3B (0.63) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL4491218 | 0.86 | GSK3B (0.61) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL1462380 | 0.86 | GSK3B (1.00) | GSK3BCYP1A2CDK2GSK3AHDAC1 | |
| SCHEMBL4497067 | 0.84 | GSK3B (0.64) | GSK3BCYP1A2 | |
| SCHEMBL4486435 | 0.84 | GSK3B (0.85) | GSK3BCYP1A2CDK2GSK3AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |