Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494700 | 0.89 | — | — | |
| SCHEMBL1818364 | 0.88 | — | — | |
| SCHEMBL2168845 | 0.80 | — | — | |
| SCHEMBL1736514 | 0.78 | — | — | |
| SCHEMBL5791100 | 0.75 | — | — | |
| SCHEMBL17013649 | 0.73 | ALDH1A1 (0.32) | ALDH1A1THRB | |
| SCHEMBL15292537 | 0.73 | CYP3A4 (0.37) | ALDH1A1THRB | |
| SCHEMBL1297592 | 0.73 | — | — | |
| SCHEMBL7848246 | 0.73 | — | — | |
| SCHEMBL6130189 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872842-B2 | Antileukemia and antitumor agents | FLORIDA STATE UNIVERSITY (US) | 2005-03-29 | — | — | US | claimed |
| US-6693200-B2 | IP RECEPTOR ANTAGONISTS; ANTIINFLAMMATORIES AND ANALGESICS | SYNTEX (U.S.A.) LLC | 2004-02-17 | — | — | US | claimed |
| US-20030114419-A1 | Taxane derivatives having a tricyclic or tetracyclic core; remarkable properties in vitro; valuable antileukemia, antitumor and anticarcinogenic agents; human cancer cell line comparable to that of taxol and taxotere | FLORIDA STATE UNIVERSITY | 2003-06-19 | — | — | US | claimed |
| US-20030055272-A1 | Antileukemia and antitumor agents | FLORIDA STATE UNIVERSITY | 2003-03-20 | — | — | US | claimed |
| US-20030045531-A1 | Antileukemia and antitumor agents | FLORIDA STATE UNIVERSITY | 2003-03-06 | — | — | US | claimed |
| EP-0681573-B1 | C2 Taxane derivatives and pharmaceutical compositions containing them | UNIV FLORIDA STATE (US) | 2002-07-03 | — | — | EP | claimed |
| EP-0688212-B1 | C9 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | UNIV FLORIDA STATE (US) | 2002-06-12 | — | — | EP | claimed |
| US-20020058821-A1 | C2 substituted taxanes | FLORIDA STATE UNIVERSITY | 2002-05-16 | — | — | US | claimed |
| US-20020002292-A1 | Antitumor agents | HOLTON ROBERT A (US) | 2002-01-03 | — | — | US | claimed |
| EP-0690712-B1 | TAXANES HAVING A PYRIDYL SUBSTITUTED SIDE-CHAIN | UNIV FLORIDA STATE (US) | 2001-11-28 | — | — | EP | claimed |
| EP-0681574-A1 | C7 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1995-11-15 | — | — | EP | claimed |
| EP-0681573-A1 | C2 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1995-11-15 | — | — | EP | claimed |
| EP-0679082-A1 | C10 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | FLORIDA STATE UNIVERSITY (US) | 1995-11-02 | — | — | EP | claimed |
| EP-0668762-A1 | BUTENYL-SUBSTITUTED TAXANES AND COMPOSITION | FLORIDA STATE UNIVERSITY (US) | 1995-08-30 | — | — | EP | claimed |
| WO-1994021252-A1 | TAXANES HAVING A PYRIDYL SUBSTITUTED SIDE-CHAIN | FLORIDA STATE UNIVERSITY (US) | 1994-09-29 | — | — | WO | claimed |
| WO-1994020088-A1 | C9 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1994-09-15 | — | — | WO | claimed |
| WO-1994017050-A1 | C7 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1994-08-04 | — | — | WO | claimed |
| WO-1994017052-A1 | C2 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1994-08-04 | — | — | WO | claimed |
| WO-1994015599-A1 | C10 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | FLORIDA STATE UNIVERSITY (US) | 1994-07-21 | — | — | WO | claimed |
| WO-1994010996-A1 | BUTENYL-SUBSTITUTED TAXANES AND COMPOSITION | FLORIDA STATE UNIVERSITY (US) | 1994-05-26 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045531-A1 | Antileukemia and antitumor agents | MCL1, BCL3, BCL2L13 | ALDH1A1 990/4885TSHR 3954/4885THRB 3545/4885 |
| US-20030114419-A1 | Taxane derivatives having a tricyclic or tetracyclic core; remarkable properties in vitro; valuable antileukemia, antitumor and anticarcinogenic agents; human cancer cell line comparable to that of taxol and taxotere | MCL1, TOP2A, TOP2B | ALDH1A1 2877/4885TSHR 3304/4885THRB 2947/4885 |
| US-20020058821-A1 | C2 substituted taxanes | PARP2, MCL1, TOP2A | ALDH1A1 2165/4885TSHR 4044/4885THRB 3894/4885 |
| US-20020002292-A1 | Antitumor agents | TP53, MCL1, TOP2A | ALDH1A1 407/4885TSHR 2769/4885THRB 3323/4885 |
| US-20030055272-A1 | Antileukemia and antitumor agents | MCL1, BCL3, BCL9 | ALDH1A1 1033/4885TSHR 3566/4885THRB 3717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.