SCHEMBL4486696

SCHEMBL4486696

c1ccc(C2N=NN=N2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.36
MAOB P27338 8/20 0.35
MAOA P21397 7/20 0.35
KDM1A O60341 5/20 0.35
CYP2C19 P33261 4/20 0.35
CYP2B6 P20813 3/20 0.35
CYP1A2 P05177 3/20 0.35
LMNA P02545 3/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP3A4 P08684 2/20 0.35
TAAR1 Q96RJ0 2/20 0.35
HTR1A P08908 1/20 0.35
ADRA2A P08913 1/20 0.35
CYP2A6 P11509 1/20 0.35
SLC6A2 P23975 1/20 0.35
HTR2C P28335 1/20 0.35
ADRA1A P35348 1/20 0.35
DRD3 P35462 1/20 0.35
SLC6A3 Q01959 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL587341 0.88
SCHEMBL12215973 0.71 TSHR (0.36) TSHRMAOBMAOAKDM1ACYP2C19
SCHEMBL12215971 0.69 TSHR (0.31) TSHRMAOBMAOAKDM1ACYP2C19
SCHEMBL4267200 0.69 TSHR (0.35) TSHRMAOBMAOAKDM1ACYP2C19
SCHEMBL12215976 0.69 GAA (0.40) TSHRMAOBMAOAKDM1ACYP2C19
SCHEMBL10022691 0.67 HPGD (0.42) LMNAKDM4EMAPTTP53
SCHEMBL20511049 0.64 TSHR (0.31) TSHRMAOBMAOAKDM1ACYP2C19
SCHEMBL2031804 0.63 HDAC4 (0.46) TSHRMAOBMAOAKDM1ACYP2C19
SCHEMBL31041077 0.63 HDAC4 (0.46) TSHRMAOBMAOAKDM1ACYP2C19
SCHEMBL6268220 0.63 MAOB (0.50) TSHRMAOBMAOAKDM1ACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109438914-A A kind of foamed polyether ether ketone material 嘉兴博发新型塑料有限公司 2019-03-08 CN claimed
CN-108290373-A The reinforcement of foaminess plate supporting material, its manufacturing method and plate 积水化成品工业株式会社 2018-07-17 CN claimed
CN-108250669-A A kind of polyether-ether-ketone expanded material and preparation method thereof 宜宾天原集团股份有限公司 2018-07-06 CN claimed
CN-104860908-B Method for synthesizing BNC105 广东颐正达医药科技有限公司 2017-03-22 CN claimed
CN-104860908-A Method for synthesizing BNC105 GUANGDONG YIZHENGDA PHARMACEUTICAL TECHNOLOGY CO LTD 2015-08-26 CN claimed
US-20150150893-A1 ANDROGRAPHOLIDE ANALOGS AND THEIR USE FOR MEDICATION LIAONING LIFENG SCIENT & TECHNOLOGY DEV COMPANY LTD (CN) 2015-06-04 US claimed
US-7569580-B2 Tetrazolo[1,5-a]thieno[2,3-e]pyridine-4-carboxylic acid RIGEL PHARMACEUTICALS, INC. (US) 2009-08-04 US claimed
CN-1192696-A Spironolactone and angiotensin 2 antagonist combination therapy for treatment of congestive heart failure SEARLE & CO (US) 1998-09-09 CN claimed
CN-119528837-A Synthesis process of 5-phenyl tetrazole 山东青科农牧发展有限公司 2025-02-28 CN disclosed
CN-106029746-B Foamed material 索尔维特殊聚合物美国有限责任公司 2019-06-14 CN disclosed
CN-105418526-B One kind has compound and its application of single sulphenyl tetrazole structure 杭州伽玛生物科技有限公司 2019-02-15 CN disclosed
CN-108350583-A By the power cable for the aluminium that tetrazole compound corrosion inhibitor coats 普睿司曼股份公司 2018-07-31 CN disclosed
CN-108290373-A The reinforcement of foaminess plate supporting material, its manufacturing method and plate 积水化成品工业株式会社 2018-07-17 CN disclosed
CN-105793041-B Original edition of lithographic printing plate and monomer 爱克发有限公司 2018-04-27 CN disclosed
CN-1142056-C Foamed polymer-fiber composite ����̹�ص¹�˾ 2004-03-17 CN disclosed
CN-1298342-A Foamed polymer-fiber composite CERTAIN TEED CORP (US) 2001-06-06 CN disclosed
CN-1189158-A Novel reagent for synthesizing tetrazole and method for synthesizing tetrazole using same CHUGOKU KAYAKU (JP) 1998-07-29 CN disclosed
CN-1039324-C Substituted azacyclo-pyrimidine compounds, their pharmaceutical salts or N-oxides, and their use as anti-inflammatory agents AMERICAN HOME PROD (US) 1998-07-29 CN disclosed
CN-1175414-A Method for preparing substd. azacyclopyrimidine compound, its pharmaceutic salt or N-oxide AMERICAN HOME PROD (US) 1998-03-11 CN disclosed
CN-1134935-A Herbicidal (1,3,4) oxadiazoles and thiadiazoles AMERICAN CYANAMID CO (US) 1996-11-06 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150150893-A1 ANDROGRAPHOLIDE ANALOGS AND THEIR USE FOR MEDICATION CYP11B1, CYP51A1, CYP11B2 TSHR 4310/4885MAOB 3234/4885MAOA 3443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.