Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503736 | 0.93 | HDAC1 (0.51) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL12886266 | 0.86 | DRD2 (0.47) | DRD2GSK3AGSK3B | |
| SCHEMBL12886031 | 0.86 | RAB9A (0.45) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL4486750 | 0.85 | HDAC1 (0.59) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4494353 | 0.84 | HDAC1 (0.67) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4482771 | 0.81 | HDAC1 (0.67) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4488525 | 0.81 | HDAC1 (0.60) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4492950 | 0.80 | HDAC1 (0.65) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4501959 | 0.79 | FGFR1 (0.59) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4480272 | 0.78 | HDAC1 (0.66) | HDAC1HDAC2HDAC8FGFR1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |