SCHEMBL44869

SCHEMBL44869

Nc1nc(-c2ccccc2)cs1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 1.00
RAB9A P51151 8/20 0.92
MAPT P10636 7/20 0.92
NPC1 O15118 6/20 0.92
KMT2A Q03164 5/20 0.92
SMN1; SMN2 Q16637 5/20 0.92
KDM4E B2RXH2 5/20 0.92
MEN1 O00255 4/20 0.92
NFKB1 P19838 2/20 0.92
NFKB2 Q00653 2/20 0.92
RELA Q04206 2/20 0.92
LMNA P02545 1/20 0.92
CYP3A4 P08684 1/20 0.92
LTA4H P09960 3/20 0.70
MKNK1 Q9BUB5 1/20 0.64
MKNK2 Q9HBH9 1/20 0.64
ALOX5 P09917 1/20 0.64
GFER P55789 2/20 0.63
AR P10275 2/20 0.63
HPGD P15428 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL7128948 0.98 ALDH1A1 (0.96) ALDH1A1RAB9AMAPTNPC1KMT2A
Bromide SCHEMBL5325472 0.96 ALDH1A1 (1.00) ALDH1A1RAB9AMAPTNPC1KMT2A
Hydrochloric Acid SCHEMBL5450269 0.96 ALDH1A1 (0.92) ALDH1A1RAB9AMAPTNPC1KMT2A
SCHEMBL2907964 0.96 ALDH1A1 (1.00) ALDH1A1RAB9AMAPTNPC1KMT2A
SCHEMBL11505502 0.89 ALDH1A1 (0.79) ALDH1A1RAB9AMAPTNPC1KMT2A
SCHEMBL1771825 0.88 ALDH1A1 (0.79) ALDH1A1RAB9AMAPTNPC1KMT2A
SCHEMBL1399840 0.86 ALDH1A1 (0.76) ALDH1A1RAB9AMAPTNPC1KMT2A
SCHEMBL23610361 0.86 ALDH1A1 (0.83) ALDH1A1RAB9AMAPTNPC1KMT2A
Iodide SCHEMBL5460208 0.86 RAB9A (0.87) ALDH1A1RAB9AMAPTNPC1KMT2A
SCHEMBL11440336 0.85 ALDH1A1 (0.73) ALDH1A1RAB9AMAPTNPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1341 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120166857-A Photoelectric device, preparation method thereof and display device TCL科技集团股份有限公司 2025-06-17 CN claimed
CN-119661467-A Synthesis process of N- (4-phenylthiazole-2-yl) -3- (4-benzylpiperazine-1-yl) propionamide monohydrochloride 武汉亿诺药业有限公司 2025-03-21 CN claimed
CN-119255993-A Thiazole derivative compound and use thereof 奥托泰利克生物公司 2025-01-03 CN claimed
CN-118459420-A Thiazolinone compound containing multiple halogen atoms and preparation method thereof 南京工业大学 2024-08-09 CN claimed
CN-118221610-A Phenylthiazole amine PI4KIII beta/HDAC double-target inhibitor, preparation method, pharmaceutical composition and application thereof 南京市鸿舜医药科技有限公司 2024-06-21 CN claimed
CN-117534631-B Phenylthiazole amine PI4KIII beta inhibitor, preparation method, pharmaceutical composition and application thereof 南京市鸿舜医药科技有限公司 2024-04-05 CN claimed
CN-117757073-A Polyamide acid solution and preparation method and application thereof 上海瑛泰医疗器械股份有限公司 2024-03-26 CN claimed
CN-117534631-A Phenylthiazole amine PI4KIII beta inhibitor, preparation method, pharmaceutical composition and application thereof 南京市鸿舜医药科技有限公司 2024-02-09 CN claimed
CN-117383994-A Preparation method of asymmetric urea compound and asymmetric urea compound 内蒙古工业大学 2024-01-12 CN claimed
CN-116693466-A Gallic acid derivative containing thiazole structure and synthesis method and application thereof 江苏海洋大学 2023-09-05 CN claimed
EP-0263020-A1 4-Phenyl thiazole derivatives LABORATOIRE L. LAFON Société anonyme dite: (FR) 1988-04-06 EP claimed
EP-0172427-A2 Process for production of vinyl chloride polymer Shin-Etsu Chemical Co., Ltd. (JP) 1986-02-26 EP claimed
EP-0068033-B1 N-(4-PHENYL-2-THIAZOLYL)CARBAMATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) 1985-07-10 EP claimed
US-4496727-A ORGANIC PIGMENTS; PLASTICS; LACQUERS; INKS; COATINGS; COLOR FASTNESS CIBA-GEIGY CORPORATION (US) 1985-01-29 US claimed
US-4385174-A FOR PIGMENTS CIBA-GEIGY CORPORATION (US) 1983-05-24 US claimed
EP-0068033-A1 N-(4-PHENYL-2-THIAZOLYL)CARBAMATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) 1983-01-05 EP claimed
US-4349671-A Process for the production of metal complexes of isoindoline azines CIBA-GEIGY CORPORATION (US) 1982-09-14 US claimed
EP-0006368-B1 4-PHENYL-THIAZOLYL-2-OXAMATE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF ASTHMA PIERRE FABRE S.A. (FR) 1981-11-18 EP claimed
EP-0001727-B1 NEW DERIVATIVES OF 4-PHENYL-2-(2',2',2-TRICHLORETHOXYCARBOXAMIDO)-THIAZOLE USEFUL AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THE PREPARATION OF THESE COMPOUNDS PIERRE FABRE S.A. (FR) 1981-11-11 EP claimed
US-4225610-A TREATMENT OF RHEUMATOID ARTHRITIS PIERRE FABRE, S.A. (FR) 1980-09-30 US claimed