Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 6/20 | 0.75 |
| ▸ | CDK2 | P24941 | 6/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.68 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.68 |
| ▸ | TUBB | P07437 | 1/20 | 0.68 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.68 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.68 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.68 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.68 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.68 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.68 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.68 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.68 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.67 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476842 | 0.90 | MAPT (0.73) | CCNA2CDK2MAPTMEN1KMT2A | |
| SCHEMBL13633843 | 0.88 | CCNA2 (0.78) | CCNA2CDK2MAPTNPC1CDK5 | |
| SCHEMBL4478062 | 0.87 | CCNA2 (0.87) | CCNA2CDK2MAPTMEN1KMT2A | |
| SCHEMBL4477981 | 0.85 | CDK5 (0.81) | CCNA2CDK2MAPTMEN1KMT2A | |
| SCHEMBL163591 | 0.84 | CDK5 (0.91) | CCNA2CDK2MAPTMEN1KMT2A | |
| SCHEMBL6194139 | 0.83 | CCNA2 (0.62) | CCNA2CDK2MAPTTUBB8BTUBB4A | |
| SCHEMBL4397229 | 0.83 | MEN1 (1.00) | CCNA2CDK2MAPTMEN1KMT2A | |
| SCHEMBL20142286 | 0.82 | ZAP70 (0.72) | CCNA2CDK2MAPTMEN1KMT2A | |
| SCHEMBL4473183 | 0.82 | CCNA2 (0.88) | CCNA2CDK2MAPTMEN1KMT2A | |
| SCHEMBL20142352 | 0.82 | CCNA2 (0.77) | CCNA2CDK2MAPTNPC1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20060041006-A1 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PDE4B, PDE7B, PDE4A | CCNA2 4015/4885CDK2 1537/4885MAPT 3524/4885 |
| US-20060041006-A1 | PDE4B inhibitors and uses therefor | PDE4B, PDE7B, PDE4A | CCNA2 4015/4885CDK2 1537/4885MAPT 3524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.