Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.32 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12056714 | 0.75 | SCN5A (0.54) | SCN5AMCHR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL15068590 | 0.74 | CA2 (0.43) | MCHR1KDM4ENPC1ALDH1A1POLB | |
| SCHEMBL516957 | 0.74 | PIK3CG (0.55) | SCN5AMCHR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL8812209 | 0.74 | SCN5A (0.53) | SCN5AKDM4ENPC1ALDH1A1POLB | |
| SCHEMBL18080888 | 0.74 | SCN5A (0.53) | SCN5AMCHR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL2118968 | 0.74 | SCN5A (0.53) | SCN5AMCHR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL26907587 | 0.74 | PIK3CG (0.55) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL517211 | 0.73 | SCN5A (0.49) | SCN5AMCHR1ALDH1A1 | |
| SCHEMBL16739619 | 0.72 | KDM4E (0.50) | SCN5AMCHR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL15829424 | 0.71 | SCN5A (0.50) | SCN5AMCHR1KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615639-B2 | 1-pyridyl-benzofuro[3,2-b]pyridin-2(1H)-ones | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2009-11-10 | — | — | US | disclosed |
| US-7615639-B2 | 1-pyridyl-benzofuro[3,2-b]pyridin-2(1H)-ones | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2009-11-10 | — | — | US | disclosed |
| US-7615639-B2 | 1-pyridyl-benzofuro[3,2-b]pyridin-2(1H)-ones | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2009-11-10 | — | — | US | disclosed |
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-11-15 | — | — | US | disclosed |
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-11-15 | — | — | US | disclosed |
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-11-15 | — | — | US | disclosed |
| EP-1758911-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005111047-A1 | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265295-A1 | 1-Heterocyclyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | CBR1, HRH4, CYP4B1 | SCN5A 499/4885MGLL 2422/4885MCHR1 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.