Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30100329 | 0.86 | SCN5A (0.47) | KDM4EALDH1A1MEN1HSP90AA1KMT2A | |
| SCHEMBL4781728 | 0.84 | ALDH1A1 (0.53) | KDM4EALDH1A1MEN1HSP90AA1KMT2A | |
| SCHEMBL22747159 | 0.78 | HDAC4 (0.52) | KDM4EALDH1A1SCN5AMCHR1HDAC4 | |
| SCHEMBL9753842 | 0.76 | PTGS1 (0.59) | KDM4EALDH1A1MEN1HSP90AA1KMT2A | |
| SCHEMBL1105925 | 0.75 | ALDH1A1 (0.54) | KDM4EALDH1A1MEN1HSP90AA1KMT2A | |
| SCHEMBL28360462 | 0.75 | ALDH1A1 (0.50) | KDM4EALDH1A1MEN1HSP90AA1KMT2A | |
| SCHEMBL12056714 | 0.74 | SCN5A (0.54) | KDM4EALDH1A1MEN1KMT2ASCN5A | |
| SCHEMBL38662516 | 0.74 | MCHR1 (0.53) | KDM4EALDH1A1SCN5AMCHR1SMN1; SMN2 | |
| SCHEMBL18080888 | 0.73 | SCN5A (0.53) | KDM4EALDH1A1HSP90AA1SCN5AMCHR1 | |
| SCHEMBL2118968 | 0.73 | SCN5A (0.53) | KDM4EALDH1A1SCN5AMCHR1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071553-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC Therapeutics, Inc. (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |