Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.57 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 1/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688306 | 1.00 | PTGS2 (0.61) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL10936588 | 0.89 | TSHR (0.52) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL59197 | 0.88 | PTGS2 (0.74) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| Benzoic Acid SCHEMBL8935150 | 0.87 | PTGS2 (0.62) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| Benzoic Acid SCHEMBL5786013 | 0.87 | PTGS2 (0.62) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL8833485 | 0.86 | TSHR (0.55) | PTGS2TSHRTP53ALDH1A1HPGD | |
| SCHEMBL5569785 | 0.84 | TSHR (0.52) | PTGS2TSHRTP53ALDH1A1HPGD | |
| SCHEMBL10958350 | 0.84 | PTGS2 (0.59) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL9577279 | 0.83 | TSHR (0.50) | PTGS2CYP2C9TSHRTP53ALDH1A1 | |
| SCHEMBL6070671 | 0.83 | PTGS2 (0.57) | PTGS2PTGS1CYP2C9LMNAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119064487-A | Method for detecting related substances of loxoprofen sodium gel plaster | 江苏济茗医药有限公司 | 2024-12-03 | — | — | CN | claimed |
| CN-109180507-B | Ketoprofen hapten, artificial antigen and antibody, and preparation method and application thereof | 北京勤邦生物技术有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-109180507-A | Ketoprofen haptens, artificial antigen and antibody and its preparation method and application | 北京勤邦生物技术有限公司 | 2019-01-11 | — | — | CN | claimed |
| US-4031167-A | COATINGS | INTERNATIONAL TELEPHONE AND TELEGRAPH CORPORATION (US) | 1977-06-21 | — | — | US | claimed |
| CN-109180507-B | Ketoprofen hapten, artificial antigen and antibody, and preparation method and application thereof | 北京勤邦生物技术有限公司 | 2022-10-21 | — | — | CN | disclosed |
| WO-2019233215-A1 | HIGH WATER-REDUCING AND LOW SENSITIVITY POLYCARBOXYLATE SUPERPLASTICIZER AND PREPARATION METHOD THEREFOR | 科之杰新材料集团有限公司 (CN) | 2019-12-12 | — | — | WO | disclosed |
| CN-110294659-A | A kind of preparation method of organic carboxyl acid | 中国科学院兰州化学物理研究所苏州研究院 | 2019-10-01 | — | — | CN | disclosed |
| CN-109180507-A | Ketoprofen haptens, artificial antigen and antibody and its preparation method and application | 北京勤邦生物技术有限公司 | 2019-01-11 | — | — | CN | disclosed |
| EP-2427435-B1 | SUBSTITUTED PHENYLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS | MEDIFRON DBT INC (KR) | 2017-06-14 | — | — | EP | disclosed |
| US-9624209-B2 | Substituted phenylureas and phenylamides as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2017-04-18 | — | — | US | disclosed |
| US-9624209-B2 | Substituted phenylureas and phenylamides as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2017-04-18 | — | — | US | disclosed |
| CN-105085555-A | Dimensional cadmium polymer containing mixed ligand as well as preparation method and application thereof | UNIV QILU TECHNOLOGY | 2015-11-25 | — | — | CN | disclosed |
| WO-2010127856-A1 | SUBSTITUTED PHENYLLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2010-11-11 | — | — | WO | disclosed |
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-31 | — | — | US | disclosed |
| WO-2004091522-A2 | METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |
| US-5454910-A | Pulp-like short fibers from liquid crystal polyesters | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 1995-10-03 | — | — | US | disclosed |
| EP-0330241-A2 | Calcitonin derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0013461-B1 | PROCESS FOR THE PREPARATION OF A SEGMENTED THERMOPLASTIC ELASTOMER | AKZO N.V. (NL) | 1983-04-06 | — | — | EP | disclosed |
| EP-0013461-A1 | Process for the preparation of a segmented thermoplastic elastomer | AKZO N.V. (NL) | 1980-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | KDR, FLT1, EGFR | PTGS2 1937/4885PTGS1 1195/4885CYP2C9 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.