Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688306 | 0.89 | PTGS2 (0.61) | TSHRTP53PTGS2KMT2AALDH1A1 | |
| SCHEMBL4488292 | 0.89 | PTGS2 (0.61) | TSHRTP53PTGS2KMT2AALDH1A1 | |
| SCHEMBL8833485 | 0.84 | TSHR (0.55) | TSHRTP53PTGS2KMT2AALDH1A1 | |
| SCHEMBL28999792 | 0.84 | LMNA (0.46) | TSHRPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2000487 | 0.83 | TSHR (0.48) | TSHRTP53PTGS2KMT2AALDH1A1 | |
| SCHEMBL5569785 | 0.83 | TSHR (0.52) | TSHRTP53PTGS2KMT2AALDH1A1 | |
| SCHEMBL801382 | 0.82 | PTGS2 (0.59) | PTGS2ALDH1A1SMN1; SMN2SRD5A2PTGS1 | |
| SCHEMBL13171972 | 0.81 | PTGS2 (0.42) | TSHRPTGS2ALDH1A1PTGS1CYP2C9 | |
| SCHEMBL9577279 | 0.81 | TSHR (0.50) | TSHRTP53PTGS2KMT2AALDH1A1 | |
| SCHEMBL2149876 | 0.81 | PTGS2 (0.42) | TSHRPTGS2ALDH1A1PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4548811-A | COMPRISING A MERCAPTO AND A CYCLODEXTRIN-CARBO KETONE INCLUSION CO | SHISEIDO COMPANY LTD. (JP) | 1985-10-22 | — | — | US | claimed |
| US-4547365-A | CYCLODEXTRINS AND ALDEHYDE OR KETONE COMPOUNDS; ODORLESS | SHISEIDO COMPANY LTD. (JP) | 1985-10-15 | — | — | US | claimed |
| US-9624209-B2 | Substituted phenylureas and phenylamides as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2017-04-18 | — | — | US | disclosed |
| US-9120756-B2 | Substituted phenylureas and phenylamides as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2015-09-01 | — | — | US | disclosed |
| US-20150099728-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | MEDIFRON DBT INC. (KR) | 2015-04-09 | — | — | US | disclosed |
| US-8946204-B2 | Substituted phenylureas and phenylamides as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| US-20150011592-A9 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2015-01-08 | — | — | US | disclosed |
| US-20140142143-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2014-05-22 | — | — | US | disclosed |
| US-20120258946-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2012-10-11 | — | — | US | disclosed |
| EP-1801165-B1 | Modified carbocyanine dyes and their conjugates | LIFE TECHNOLOGIES CORP (US) | 2012-08-01 | — | — | EP | disclosed |
| US-4548811-A | COMPRISING A MERCAPTO AND A CYCLODEXTRIN-CARBO KETONE INCLUSION CO | SHISEIDO COMPANY LTD. (JP) | 1985-10-22 | — | — | US | disclosed |
| US-4547365-A | CYCLODEXTRINS AND ALDEHYDE OR KETONE COMPOUNDS; ODORLESS | SHISEIDO COMPANY LTD. (JP) | 1985-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099728-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | TRPV1, TRPV5, TRPV6 | TSHR 611/4885TP53 3587/4885PTGS2 1336/4885 |
| US-20120258946-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | TRPV1, TRPV5, TRPV6 | TSHR 611/4885TP53 3587/4885PTGS2 1336/4885 |
| US-20150011592-A9 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | TRPV1, TRPV5, TRPV2 | TSHR 662/4885TP53 3789/4885PTGS2 1571/4885 |
| US-20140142143-A1 | Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands | TRPV1, TRPV5, TRPV2 | TSHR 662/4885TP53 3789/4885PTGS2 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.