Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK14 | O94921 | 9/20 | 0.48 |
| ▸ | CCNY | Q8ND76 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | CASK | O14936 | 1/20 | 0.40 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954955 | 0.95 | KMT2A (0.51) | CDK14CCNYKMT2AMEN1JAK2 | |
| SCHEMBL8260751 | 0.89 | CDK14 (0.51) | CDK14CCNYKMT2AMEN1ALDH1A1 | |
| SCHEMBL8219606 | 0.86 | TYK2 (0.52) | CDK14CCNYKMT2AMEN1TYK2 | |
| SCHEMBL1645592 | 0.86 | JAK2 (0.52) | CDK14CCNYKMT2AMEN1JAK2 | |
| SCHEMBL5007605 | 0.84 | CDK14 (0.46) | CDK14CCNYKMT2AMEN1ALDH1A1 | |
| SCHEMBL8261624 | 0.83 | CDK14 (0.50) | CDK14CCNYKMT2AMEN1JAK2 | |
| SCHEMBL5006782 | 0.83 | TTR (0.47) | CDK14CCNYKMT2AMEN1ALDH1A1 | |
| SCHEMBL12288164 | 0.83 | CDK14 (0.53) | CDK14CCNYKMT2AMEN1JAK2 | |
| SCHEMBL8261342 | 0.82 | CDK14 (0.46) | CDK14CCNYKMT2AMEN1JAK2 | |
| SCHEMBL29035529 | 0.82 | CDK14 (0.51) | CDK14CCNYKMT2AMEN1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046327-A1 | MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS | Astex Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008009954-A1 | MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |