Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | CDK14 | O94921 | 8/20 | 0.47 |
| ▸ | CCNY | Q8ND76 | 8/20 | 0.47 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.42 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954955 | 0.91 | KMT2A (0.51) | TYK2CDK14CCNYKMT2AMEN1 | |
| SCHEMBL4488401 | 0.86 | CDK14 (0.48) | TYK2CDK14CCNYKMT2AMEN1 | |
| SCHEMBL5007605 | 0.85 | CDK14 (0.46) | CDK14CCNYKMT2AMEN1POLB | |
| SCHEMBL1645592 | 0.85 | JAK2 (0.52) | TYK2CDK14CCNYKMT2AMEN1 | |
| SCHEMBL8261339 | 0.84 | TAS1R3 (0.48) | KMT2AMEN1POLB | |
| SCHEMBL8261342 | 0.83 | CDK14 (0.46) | TYK2CDK14CCNYKMT2AMEN1 | |
| SCHEMBL12288164 | 0.82 | CDK14 (0.53) | TYK2CDK14CCNYKMT2AMEN1 | |
| SCHEMBL5006782 | 0.82 | TTR (0.47) | TYK2CDK14CCNYKMT2AMEN1 | |
| SCHEMBL8261343 | 0.82 | CDK14 (0.52) | TYK2CDK14CCNYKMT2AMEN1 | |
| SCHEMBL8044614 | 0.81 | CDK5 (0.60) | TYK2CDK14CCNYKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009954-A1 | MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |