Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TERT | O14746 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28150363 | 0.98 | TSHR (0.55) | TSHRFAAHEP300MEN1CYP3A4 | |
| SCHEMBL20917075 | 0.98 | TSHR (0.55) | TSHRFAAHEP300MEN1CYP3A4 | |
| SCHEMBL811748 | 0.98 | TSHR (0.55) | TSHRFAAHEP300MEN1CYP3A4 | |
| SCHEMBL4825341 | 0.98 | TSHR (0.55) | TSHRFAAHEP300MEN1CYP3A4 | |
| SCHEMBL3267188 | 0.92 | TSHR (0.43) | TSHRALDH1A1LMNAPOLBAPEX1 | |
| SCHEMBL767678 | 0.86 | TSHR (0.42) | TSHRALDH1A1 | |
| SCHEMBL865971 | 0.85 | TSHR (0.38) | TSHRALDH1A1 | |
| SCHEMBL3268327 | 0.83 | TSHR (0.46) | TSHRALDH1A1HSD17B10 | |
| SCHEMBL865640 | 0.83 | TSHR (0.38) | TSHRALDH1A1LMNA | |
| SCHEMBL866222 | 0.83 | TSHR (0.38) | TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968528-B1 | DENTAL COMPOSITIONS WITH SURFACE-TREATED FILLER FOR SHELF STABILITY | 3M INNOVATIVE PROPERTIES CO (US) | 2016-02-17 | — | — | EP | claimed |
| EP-3697768-B1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2023-06-07 | — | — | EP | disclosed |
| US-20210122725-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2021-04-29 | — | — | US | disclosed |
| EP-3697768-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | Merck Patent GmbH (DE) | 2020-08-26 | — | — | EP | disclosed |
| WO-2019076852-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2019-04-25 | — | — | WO | disclosed |
| US-7638641-B2 | Tetrahydropyran derivatives | MERCK PATENT GMBH (DE) | 2009-12-29 | — | — | US | disclosed |
| US-7449499-B2 | Self-etching dental compositions and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-11-11 | — | — | US | disclosed |
| US-20080045631-A1 | Silicone Topcoat With Improved Dirt Repellency and Improved Bondability, With Core-Shell Particle | WACKER CHEMIE AG (DE) | 2008-02-21 | — | — | US | disclosed |
| US-20060058527-A1 | Tetrahydropyran derivatives | MERCK PATENT GMBH (DE) | 2006-03-16 | — | — | US | disclosed |
| US-20060057190-A1 | Silicone topcoat with improved dirt repellency and improved bondability | WACKER-CHEMIE GMBH (DE) | 2006-03-16 | — | — | US | disclosed |
| US-20050175965-A1 | Self-etching dental compositions and methods | 3M DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210122725-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | DDT, BPTF, CCNT1 | TSHR 1794/4885FAAH 2905/4885EP300 1279/4885 |
| US-20060058527-A1 | Tetrahydropyran derivatives | HPD, CYP3A43, CYP1A2 | TSHR 2675/4885FAAH 2826/4885EP300 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.