⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14777872 | 0.80 | THRB (0.32) | — | |
| SCHEMBL7653955 | 0.79 | THRB (0.31) | — | |
| SCHEMBL2956144 | 0.78 | — | — | |
| SCHEMBL6721190 | 0.76 | THRB (0.36) | — | |
| SCHEMBL31038071 | 0.75 | ALDH1A1 (0.44) | — | |
| SCHEMBL28779842 | 0.74 | ALDH1A1 (0.36) | — | |
| SCHEMBL7848246 | 0.73 | — | — | |
| SCHEMBL17013649 | 0.73 | ALDH1A1 (0.32) | — | |
| SCHEMBL1074130 | 0.73 | — | — | |
| SCHEMBL31296252 | 0.73 | THRB (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109438431-B | Preparation method of lamivudine | 武汉工程大学 | 2022-01-11 | — | — | CN | disclosed |
| CN-109438431-A | A kind of preparation method of Lamivudine | 武汉工程大学 | 2019-03-08 | — | — | CN | disclosed |
| CN-108699019-A | Benzofuran derivatives useful in the treatment of central nervous system and other diseases | 华纳巴布科克绿色化学学院有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-103694231-A | Synthesis and preparation method of lamivudine intermediate HDMS | ANHUI PROVINCE YIFAN SPICE CO LTD | 2014-04-02 | — | — | CN | disclosed |
| CN-101597281-B | Preparation method of lamivudine and intermediate thereof | JINAN INOVAS CHEMICALS CO LTD | 2012-09-05 | — | — | CN | disclosed |
| CN-101830893-A | Synthesis and preparation process of lamivudine intermediate HDMS | ANHUI PROVINCE YIFAN SPICE CO LTD | 2010-09-15 | — | — | CN | disclosed |
| CN-101597281-A | Lamivudine and intermediates preparation thereof | JINAN INOVAS CHEMICAL CO LTD (CN) | 2009-12-09 | — | — | CN | disclosed |
| US-7598253-B2 | Reverse-turn mimetics and methods relating thereto | MYRIAD GENETICS, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| EP-1227813-B1 | REVERSE-TURN MIMETICS AS alpha 4ß INTEGRIN INHIBITORS | MYRIAD GENETICS INC (US) | 2007-08-22 | — | — | EP | disclosed |
| EP-1208103-B1 | REVERSE-TURN MIMETICS AND METHODS RELATING THERETO | MYRIAD GENETICS INC (US) | 2005-08-10 | — | — | EP | disclosed |
| US-6548500-B2 | Treating a cell adhesion-mediated diseases such as multiple sclerosis, asthma, atherosclerosis, rheumatoid arthritis, meningitis, comprising administering to a warm blooded animal a nitrogen atoms containing bicyclic compound | MOLECUMETICS LTD. | 2003-04-15 | — | — | US | disclosed |
| US-6440955-B1 | ANTI-INFLAMMATORY AGENTS | MOLECUMETICS LTD. | 2002-08-27 | — | — | US | disclosed |
| US-6413963-B2 | ALPHA, BETA-INTEGRIN INHIBITORS USED IN THE TREATMENT OF MULTIPLE SCLEROSIS, ATHEROSCLEROSIS, ASTHMA AND INFLAMMATORY BOWEL DISEASE | MOLECUMETICS, LTD. | 2002-07-02 | — | — | US | disclosed |
| US-20020065416-A1 | Reverse-turn mimetics and methods relating thereto | MOLECUMETICS LTD. (US) | 2002-05-30 | — | — | US | disclosed |
| EP-1208103-A2 | REVERSE-TURN MIMETICS AND METHODS RELATING THERETO | MOLECUMETICS, LTD. (US) | 2002-05-29 | — | — | EP | disclosed |
| US-20020022620-A1 | Reverse-turn mimetics and methods relating thereto | PRISM BIOLAB CORPORATION (JP) | 2002-02-21 | — | — | US | disclosed |
| US-20010039274-A1 | Reverse-turn mimetics and methods relating thereto | PRISM BIOLAB CORPORATION (JP) | 2001-11-08 | — | — | US | disclosed |
| US-6294525-B1 | DRUGS OF IMIDAZO(1,2A)PYRAZINE-1(5H) CARBOXYLATE DERIVATIVES | MOLECUMETICS LTD. | 2001-09-25 | — | — | US | disclosed |
| WO-2001016135-A2 | REVERSE-TURN MIMETICS AND METHODS RELATING THERETO | MOLECUMETICS LTD. (US) | 2001-03-08 | — | — | WO | disclosed |
| EP-0258578-B1 | LIQUID CRYSTAL COMPOUNDS HAVING ETHER TAIL MOIETY | POLAROID CORPORATION (US) | 1993-01-07 | — | — | EP | disclosed |