Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.81 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.81 |
| ▸ | SLC40A1 | Q9NP59 | 11/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | CKS1B | P61024 | 2/20 | 0.70 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.69 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.66 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633886 | 0.92 | MEN1 (1.00) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL1505430 | 0.89 | KMT2A (1.00) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL29575795 | 0.89 | KMT2A (1.00) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL7197593 | 0.89 | SLC40A1 (1.00) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL4489024 | 0.89 | SLC40A1 (0.77) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL22111633 | 0.88 | MEN1 (0.84) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL22076984 | 0.87 | MEN1 (1.00) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL30553454 | 0.87 | SLC40A1 (0.71) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL26964270 | 0.87 | SLC40A1 (0.71) | MEN1KMT2ATDP1LMNATP53 | |
| SCHEMBL4472564 | 0.85 | MEN1 (0.79) | MEN1KMT2ATDP1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470821-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20060041006-A1 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PDE4B, PDE7B, PDE4A | MEN1 2737/4885KMT2A 2234/4885TDP1 83/4885 |
| US-20060041006-A1 | PDE4B inhibitors and uses therefor | PDE4B, PDE7B, PDE4A | MEN1 2737/4885KMT2A 2234/4885TDP1 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.