Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2417552 | 0.90 | MAPT (0.49) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL2419071 | 0.85 | JAK2 (0.47) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL2421378 | 0.84 | RAB9A (0.49) | RXFP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2414984 | 0.82 | ALDH1A1 (0.45) | MEN1KMT2AMAPTALDH1A1CYP1A2 | |
| SCHEMBL2414579 | 0.81 | NPC1 (0.46) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL2421337 | 0.80 | JAK2 (0.52) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL2416483 | 0.80 | MEN1 (0.53) | RXFP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2417220 | 0.80 | MAPT (0.49) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL2412480 | 0.80 | NPC1 (0.64) | RXFP1MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2415770 | 0.80 | JAK2 (0.47) | ALDH1A1POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541378-B2 | Condensed heterocyclic pyrazole derivatives as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2009-06-02 | — | — | US | claimed |