Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 6/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12886200 | 0.94 | MAPK1 (0.56) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4492154 | 0.93 | MAPK1 (0.56) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4480524 | 0.88 | AAK1 (0.58) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4494147 | 0.88 | HDAC1 (0.57) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4494405 | 0.87 | GSK3B (0.55) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL12886132 | 0.86 | MAPK1 (0.49) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4485793 | 0.86 | MAPK1 (0.54) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4504003 | 0.84 | GSK3B (0.57) | MAPK1GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4480187 | 0.84 | GSK3B (0.59) | GSK3BFGFR1FGFR2FGFR3CYP1A2 | |
| SCHEMBL4494624 | 0.83 | GSK3B (0.53) | GSK3BFGFR1FGFR2FGFR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |