Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511299 | 0.89 | IKBKB (0.33) | IKBKBSMYD3 | |
| SCHEMBL4507280 | 0.72 | IKBKB (0.33) | IKBKBKDM4E | |
| SCHEMBL13993533 | 0.70 | KDM4E (0.45) | IKBKBKDM4E | |
| SCHEMBL3549851 | 0.69 | PIK3CD (0.32) | IKBKBKDM4E | |
| SCHEMBL2422835 | 0.69 | IKBKB (0.39) | IKBKBKDM4E | |
| SCHEMBL4506004 | 0.69 | HRH3 (0.31) | — | |
| SCHEMBL4504695 | 0.69 | PARP1 (0.38) | SMYD3 | |
| SCHEMBL477419 | 0.68 | KMT2A (0.41) | IKBKBKDM4E | |
| SCHEMBL22600426 | 0.68 | LMNA (0.47) | KDM4E | |
| SCHEMBL4515458 | 0.67 | SMYD3 (0.40) | IKBKBSMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275567-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275567-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | CCNI, MKI67, CDK2 | IKBKB 172/4885KDM4E 1663/4885SMYD3 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.