Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482561 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HTTKMT2ACYP2C19 | |
| SCHEMBL4496567 | 0.73 | ALDH1A1 (0.45) | ALDH1A1HPGDSMN1; SMN2HTTPOLB | |
| SCHEMBL10624241 | 0.71 | ALDH1A1 (0.48) | ALDH1A1RAB9ASMN1; SMN2HTTKMT2A | |
| SCHEMBL8031705 | 0.68 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL8031703 | 0.68 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL8031704 | 0.68 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL2264964 | 0.67 | MCL1 (0.70) | ALDH1A1HPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL28992212 | 0.67 | ALDH1A1 (1.00) | ALDH1A1HPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL15562668 | 0.67 | HPGD (1.00) | ALDH1A1HPGDRAB9ASMN1; SMN2LMNA | |
| SCHEMBL5861356 | 0.67 | ALDH1A1 (1.00) | ALDH1A1HPGDRAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619086-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20080139579-A1 | Hiv Integrase Inhibitors | MERCK & CO., INC. (US) | 2008-06-12 | — | — | US | disclosed |
| EP-1725535-A2 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005086700-A2 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139579-A1 | Hiv Integrase Inhibitors | INTS9, CDK9, PRDM9 | ALDH1A1 3596/4885HPGD 4046/4885RAB9A 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.