Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.60 |
| ▸ | GSK3B | P49841 | 7/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489466 | 0.86 | GSK3B (0.54) | AAK1GSK3BHDAC6GSK3AMAPK1 | |
| SCHEMBL4494393 | 0.85 | GSK3B (0.68) | AAK1GSK3BHDAC6GSK3AMAPK1 | |
| SCHEMBL12886189 | 0.85 | GSK3B (0.52) | AAK1GSK3BHDAC6GSK3AMAPK1 | |
| SCHEMBL4502197 | 0.84 | AAK1 (0.64) | AAK1GSK3BHDAC6GSK3ACYP1A2 | |
| SCHEMBL4498312 | 0.83 | GSK3B (0.49) | AAK1GSK3BHDAC6GSK3AMAPK1 | |
| SCHEMBL4497666 | 0.83 | GSK3B (0.69) | AAK1GSK3BHDAC6GSK3ACYP1A2 | |
| SCHEMBL4499436 | 0.83 | HDAC6 (0.66) | AAK1GSK3BHDAC6GSK3A | |
| SCHEMBL12886043 | 0.83 | GSK3B (0.51) | AAK1GSK3BHDAC6GSK3AMAPK1 | |
| SCHEMBL12886141 | 0.82 | ABL1 (0.51) | AAK1GSK3BHDAC6MAPK1CYP1A2 | |
| SCHEMBL4503079 | 0.81 | HDAC6 (0.69) | AAK1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |