Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.66 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 7/20 | 0.57 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494393 | 0.88 | GSK3B (0.68) | HDAC6AAK1HDAC1HDAC2HDAC8 | |
| SCHEMBL4502197 | 0.87 | AAK1 (0.64) | HDAC6AAK1GSK3BGSK3A | |
| SCHEMBL1461281 | 0.86 | GSK3B (0.66) | HDAC6AAK1HDAC1HDAC2HDAC8 | |
| SCHEMBL4497666 | 0.86 | GSK3B (0.69) | HDAC6AAK1GSK3BGSK3A | |
| SCHEMBL4489062 | 0.86 | HDAC6 (0.65) | HDAC6AAK1HDAC1HDAC2HDAC8 | |
| SCHEMBL4559708 | 0.85 | ADORA3 (0.58) | HDAC6AAK1HDAC1HDAC2HDAC8 | |
| SCHEMBL4502227 | 0.85 | HDAC6 (0.55) | HDAC6AAK1HDAC1HDAC2HDAC8 | |
| SCHEMBL4482280 | 0.84 | AAK1 (0.58) | HDAC6AAK1GSK3BGSK3A | |
| SCHEMBL4503079 | 0.84 | HDAC6 (0.69) | HDAC6AAK1HDAC1HDAC2HDAC8 | |
| SCHEMBL4493555 | 0.83 | AAK1 (0.60) | HDAC6AAK1GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |