Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32670789 | 1.00 | MAPT (0.56) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL29395986 | 1.00 | MAPT (0.56) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| Cyclohexane SCHEMBL28734369 | 0.96 | MAPT (0.57) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL4494083 | 0.86 | MAPT (0.59) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL4932028 | 0.85 | TDP1 (0.62) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL28683901 | 0.85 | MAPT (0.58) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL18073557 | 0.85 | KDM4E (0.57) | MAPTKDM4EMEN1CYP1A2CYP2C19 | |
| SCHEMBL29800523 | 0.83 | TDP1 (0.72) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL4927155 | 0.83 | TDP1 (0.65) | MAPTTAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL4483530 | 0.81 | THRB (0.53) | MAPTTAS1R3TAS1R1TAS1R2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057636-A | Preparation process of 2-chloro-3-N- (2, 4-difluorophenyl) nicotinamide | 江苏颖盛化工有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-104402814-A | Method for synthesizing 2-chlorine-N-(2,4-difluorophenyl) nicotinamide by one-pot method | NANTONG JIAHE CHEMICALS CO LTD | 2015-03-11 | — | — | CN | claimed |
| CN-114634444-A | Preparation method of amide compound | 泰州百力化学股份有限公司 | 2022-06-17 | — | — | CN | disclosed |
| CN-114380740-A | Synthesis method of polysubstituted pyridine-2-oxygen ether compound | 江阴苏利化学股份有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-216063261-U | Chlorination reation kettle is used in nicotinamide preparation | 江苏颖盛化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-216063261-U | Chlorination reation kettle is used in nicotinamide preparation | 江苏颖盛化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-216062658-U | Hydrogen chloride tail gas processing apparatus is used in nicotinamide production | 江苏颖盛化工有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114057636-A | Preparation process of 2-chloro-3-N- (2, 4-difluorophenyl) nicotinamide | 江苏颖盛化工有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-114057636-A | Preparation process of 2-chloro-3-N- (2, 4-difluorophenyl) nicotinamide | 江苏颖盛化工有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-114057636-A | Preparation process of 2-chloro-3-N- (2, 4-difluorophenyl) nicotinamide | 江苏颖盛化工有限公司 | 2022-02-18 | — | — | CN | disclosed |
| EP-1937682-B1 | MET KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-08-12 | — | — | EP | disclosed |
| US-20070078140-A1 | MET kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-05 | — | — | US | disclosed |
| US-20070078140-A1 | MET kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-05 | — | — | US | disclosed |
| US-20070078140-A1 | MET kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-05 | — | — | US | disclosed |
| EP-0899262-B1 | Process for the preparation of heteroarylcarboxylic amides and esters | BASF AG (DE) | 2005-04-06 | — | — | EP | disclosed |
| US-6320053-B1 | ETHERIFICATION OF HALO-SUBSTITUTED PYRIDINE-CRABOXY ESTER OR AMIDE PREPARED FROM THE CORRESPONDING TRICHLOROMETHYL SUBSTITUTED PYRIDINE; AGROCHEMICALS OR PHARMACEUTICALS CHEMICAL INTERMEDIATES | AMERICAN CYANAMID COMPANY | 2001-11-20 | — | — | US | disclosed |
| US-6087506-A | Preparation of hetero arylcarboxamides | AMERICAN CYANAMID COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| EP-0899262-A2 | Process for the preparation of heteroarylcarboxylic amides and esters | American Cyanamid Company (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0053011-B1 | NEW HERBICIDAL NICOTINAMIDE DERIVATIVES | MAY & BAKER LIMITED (GB) | 1985-04-03 | — | — | EP | disclosed |
| EP-0053011-A1 | New herbicidal nicotinamide derivatives | MAY & BAKER LIMITED (GB) | 1982-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078140-A1 | MET kinase inhibitors | MET, ABL1, ERBB2 | MAPT 3276/4885TAS1R3 3044/4885TAS1R1 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.