Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10962863 | 0.85 | HIF1A (0.50) | PTGS2PTGS1HIF1AALDH1A1HPGD | |
| SCHEMBL9582367 | 0.82 | HIF1A (0.45) | PTGS2PTGS1HIF1AALDH1A1HPGD | |
| SCHEMBL5304916 | 0.77 | HIF1A (0.46) | PTGS2PTGS1HIF1AALDH1A1HPGD | |
| SCHEMBL30874660 | 0.76 | COXFA4 (0.53) | PTGS2PTGS1HIF1AALDH1A1HPGD | |
| SCHEMBL8066269 | 0.76 | COXFA4 (0.53) | PTGS2PTGS1HIF1AALDH1A1HPGD | |
| SCHEMBL9405208 | 0.75 | AKR1C3 (0.39) | PTGS2PTGS1HIF1AALDH1A1HPGD | |
| SCHEMBL10963991 | 0.75 | PTGS1 (0.36) | PTGS2PTGS1ALDH1A1HPGDCYP3A4 | |
| SCHEMBL16694313 | 0.75 | HIF1A (0.67) | HIF1AEPAS1COXFA4 | |
| SCHEMBL16694230 | 0.75 | HIF1A (0.67) | HIF1AEPAS1COXFA4 | |
| SCHEMBL16694229 | 0.75 | HIF1A (0.67) | HIF1AEPAS1COXFA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534903-B2 | Use of amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl-compounds in the treatment of cardiac arrhythmia and other disease states | SOLVAY PHARMACEUTICALS GMBH (DE) | 2009-05-19 | — | — | US | disclosed |
| EP-1678130-B1 | AMIDOMETHYL-SUBSTITUTED 2-(4-SULFONILAMINO)-3-HIDROXY-3,4-DIHYDRO-2H-CHROMIUM-6-YL-DERIVATIVES AND DRUGS CONTAINING SAID COMPOUNDS | SOLVAY PHARM GMBH (DE) | 2008-08-20 | — | — | EP | disclosed |
| US-20080113999-A1 | Use of Amidomethyl-Substituted 2-(4-Sulfonylamino)-3-Hydroxy-3,4-Dihydro-2H-Chromen-6-yl-Compounds in the Treatment of Cardiac Arrhythmia and Other Disease States | SOLVAY PHARMACEUTICALS GMBH (DE) | 2008-05-15 | — | — | US | disclosed |
| US-7368582-B2 | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them | SOLVAY PHARMACEUTICALS GMBH (DE) | 2008-05-06 | — | — | US | disclosed |
| EP-1678130-A2 | AMIDOMETHYL-SUBSTITUTED 2-(4-SULFONILAMINO)-3-HIDROXY-3,4-DIHYDRO-2H-CHROMIUM-6-YL-DERIVATIVES AND DRUGS CONTAINING SAID COMPOUNDS | Solvay Pharmaceuticals GmbH (DE) | 2006-07-12 | — | — | EP | disclosed |
| US-20050148659-A1 | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them | SOLVAY PHARMACEUTICALS GMBH (DE) | 2005-07-07 | — | — | US | disclosed |
| WO-2005037780-A2 | AMIDOMETHYL-SUBSTITUTED 2-(4-SULFONILAMINO)-3-HIDROXY-3,4-DIHYDRO-2H-CHROMIUM-6-YL-DERIVATIVES AND DRUGS CONTAINING SAID COMPOUNDS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2005-04-28 | — | — | WO | disclosed |
| EP-0074170-B1 | CHROMAN COMPOUNDS, PROCESS FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1985-10-16 | — | — | EP | disclosed |
| US-4545993-A | ANTINFLAMMATORY AGENTS, ANTIPYRETICS, ANALGESICS | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1985-10-08 | — | — | US | disclosed |
| EP-0074170-A1 | Chroman compounds, process for producing them and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1983-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148659-A1 | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP4B1, CYP3A4 | PTGS2 1549/4885PTGS1 2100/4885HIF1A 2727/4885 |
| US-20080113999-A1 | Use of Amidomethyl-Substituted 2-(4-Sulfonylamino)-3-Hydroxy-3,4-Dihydro-2H-Chromen-6-yl-Compounds in the Treatment of Cardiac Arrhythmia and Other Disease States | KCNH1, RYR2, KCNJ2 | PTGS2 2460/4885PTGS1 2632/4885HIF1A 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.