Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13710452 | 0.93 | SCN9A (0.84) | SCN9ASCN10A | |
| SCHEMBL4505072 | 0.91 | SCN9A (1.00) | SCN9ASCN10A | |
| SCHEMBL4485082 | 0.88 | SCN9A (0.77) | SCN9ASCN10A | |
| SCHEMBL13710443 | 0.86 | SCN9A (0.74) | SCN9ASCN10A | |
| SCHEMBL4495137 | 0.82 | SCN9A (0.68) | SCN9ASCN10A | |
| SCHEMBL4510867 | 0.82 | SCN9A (0.68) | SCN9ASCN10A | |
| SCHEMBL13710363 | 0.82 | SCN9A (0.74) | SCN9ASCN10A | |
| SCHEMBL13710471 | 0.81 | SCN9A (0.67) | SCN9ASCN10A | |
| SCHEMBL13710433 | 0.81 | SCN9A (0.72) | SCN9ASCN10A | |
| SCHEMBL4512619 | 0.80 | SCN9A (0.71) | SCN9ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589116-B2 | Biaryl substituted pyrazoles as sodium channel blockers | MERCK & CO. INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589116-B2 | Biaryl substituted pyrazoles as sodium channel blockers | MERCK & CO. INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589116-B2 | Biaryl substituted pyrazoles as sodium channel blockers | MERCK & CO. INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20060183785-A1 | Biaryl substituted pyrazoles as sodium channel blockers | MERCK SHARP & DOHME CORP. | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183785-A1 | Biaryl substituted pyrazoles as sodium channel blockers | TRPV1, TRPA1, TRPV3 | SCN9A 78/4885SCN10A 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.