Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.66 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.66 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | CTPS1 | P17812 | 6/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621166 | 0.93 | HSD11B1 (0.70) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL3622396 | 0.93 | HSD11B1 (0.73) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL3613128 | 0.85 | HSD11B1 (0.72) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL3616711 | 0.85 | HSD11B1 (0.70) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL3615029 | 0.84 | HSD11B1 (0.88) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL3617614 | 0.82 | HSD11B1 (0.78) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL368251 | 0.80 | HSD11B1 (1.00) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL3622882 | 0.79 | HSD11B1 (0.82) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| SCHEMBL3611959 | 0.79 | HSD11B1 (0.81) | HSD11B1HSD17B1HSD17B2KMT2APOLB | |
| Hydrochloric Acid SCHEMBL5692696 | 0.79 | HSD11B1 (1.00) | HSD11B1HSD17B1HSD17B2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618961-B2 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB (SE) | 2009-11-17 | — | — | US | claimed |