Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509193 | 0.79 | MAOB (0.48) | HRH3MAOBPOLBMAPTKDM4E | |
| SCHEMBL4502216 | 0.76 | HRH3 (0.45) | HRH3MAOBMETKDM4EALDH1A1 | |
| SCHEMBL4501682 | 0.74 | HRH3 (0.48) | HRH3MAOBMETHRH1POLB | |
| SCHEMBL4501879 | 0.73 | HRH3 (0.52) | HRH3MAOBMET | |
| SCHEMBL4505175 | 0.72 | HRH3 (0.50) | HRH3MAOBPOLBMAPTKDM4E | |
| SCHEMBL4501323 | 0.72 | HRH3 (0.73) | HRH3MAOBKDM4E | |
| SCHEMBL4505136 | 0.72 | HRH3 (0.48) | HRH3MAOBMET | |
| SCHEMBL4490641 | 0.71 | HRH3 (0.49) | HRH3MAOBHRH1 | |
| SCHEMBL4503090 | 0.70 | HRH3 (0.73) | HRH3MAOBPOLBMAPTKDM4E | |
| SCHEMBL4506214 | 0.69 | HRH3 (0.55) | HRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608617-B2 | Naphthaline derivatives as H3 inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2009-10-27 | — | — | US | disclosed |