SCHEMBL4501682

SCHEMBL4501682

CC(O)c1cc(C(N)=O)ccc1-c1c(C(=O)O)ccc2cc(OCCCN3CCCCC3)ccc12

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 7/20 0.48
MAOB P27338 6/20 0.45
CHEK2 O96017 1/20 0.45
KDM4E B2RXH2 2/20 0.44
MET P08581 1/20 0.43
HRH1 P35367 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
DRD2 P14416 1/20 0.42
ADORA2A P29274 1/20 0.42
ADORA2B P29275 1/20 0.42
ADORA1 P30542 1/20 0.42
DRD3 P35462 1/20 0.42
ALDH1A1 P00352 1/20 0.41
POLB P06746 1/20 0.41
MAPT P10636 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4495489 0.74 HRH3 (0.48) HRH3MAOBKDM4EMETHRH1
SCHEMBL4509193 0.74 MAOB (0.48) HRH3MAOBKDM4EALDH1A1POLB
SCHEMBL30969209 0.73 HRH3 (0.66) HRH3MAOBCHEK2KDM4EPOLB
SCHEMBL4488748 0.73 HRH3 (0.77) HRH3MAOBKDM4EALDH1A1POLB
SCHEMBL4498814 0.72 MAOB (0.49) HRH3MAOBKDM4EHRH1ALDH1A1
SCHEMBL4506214 0.71 HRH3 (0.55) HRH3MAOB
SCHEMBL2002718 0.70 HRH3 (0.72) HRH3MAOBCHEK2KDM4EALDH1A1
SCHEMBL4502216 0.69 HRH3 (0.45) HRH3MAOBKDM4EMETALDH1A1
SCHEMBL4501005 0.69 MAOB (0.51) HRH3MAOBKDM4EHRH1ALDH1A1
SCHEMBL3296967 0.69 MAOB (0.79) MAOBKDM4EMETALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7608617-B2 Naphthaline derivatives as H3 inverse agonists HOFFMANN-LA ROCHE INC. (US) 2009-10-27 US disclosed