Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489156 | 0.83 | FFAR1 (0.37) | FFAR1GRM5 | |
| SCHEMBL4482502 | 0.75 | FLT4 (0.30) | — | |
| SCHEMBL4490782 | 0.73 | GRM5 (0.40) | ERN1FFAR1GRM5KDRPTGDR2 | |
| SCHEMBL4494939 | 0.72 | — | — | |
| SCHEMBL4490395 | 0.72 | — | — | |
| SCHEMBL4505401 | 0.70 | ALDH1A1 (0.30) | — | |
| SCHEMBL4491011 | 0.70 | SMN1; SMN2 (0.44) | — | |
| SCHEMBL4491755 | 0.70 | TRPV1 (0.36) | — | |
| SCHEMBL4497337 | 0.69 | — | — | |
| SCHEMBL4486266 | 0.68 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |