SCHEMBL449716

SCHEMBL449716

NC(=O)C([SiH3])[SiH3]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6533057 0.75
SCHEMBL10892230 0.75
SCHEMBL380421 0.70
SCHEMBL31663464 0.67
SCHEMBL1588902 0.67 LMNA (0.46)
SCHEMBL1633399 0.67
SCHEMBL80953 0.67
SCHEMBL506209 0.64
SCHEMBL1647840 0.64
SCHEMBL28637339 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5539126-A PROSTAGLANDIN ANALOGS, THROMBOXANE A2 RECEPTOR ANTAGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 1996-07-23 US claimed
EP-0138403-B1 PROCESS FOR PREPARING PHOSPHINIC ACID INTERMEDIATES E.R. Squibb &amp; Sons, Inc. (US) 1989-03-15 EP claimed
US-4602092-A Method for making phosphinic acid intermediates E. R. SQUIBB & SONS, INC. (US) 1986-07-22 US claimed
US-4594199-A Method for making phosphinic acid intermediates E. R. SQUIBB & SONS, INC. (US) 1986-06-10 US claimed
EP-0138403-A2 Process for preparing phosphinic acid intermediates E.R. Squibb &amp; Sons, Inc. (US) 1985-04-24 EP claimed
JP-7300457-A None JP disclosed
US-9139456-B2 Chelating compounds and immobilized tethered chelators THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2015-09-22 US disclosed
US-20120061325-A1 CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS THE CURATORS OF THE UNIVERSITY OF MISSOURI 2012-03-15 US disclosed
EP-2170909-B1 PROCESS FOR THE SILYLATION OF BETA-LACTAM COMPOUNDS DSM IP ASSETS BV (NL) 2011-01-26 EP disclosed
EP-2170909-A1 PROCESS FOR THE SILYLATION OF BETA-LACTAM COMPOUNDS DSM IP Assets B.V. (NL) 2010-04-07 EP disclosed
WO-2009016170-A1 PROCESS FOR THE SILYLATION OF BETA-LACTAM COMPOUNDS DSM IP ASSETS B.V. (NL) 2009-02-05 WO disclosed
US-7338669-B2 Inorganic boranophosphate salts BAR-ILAN UNIVERSITY (IL) 2008-03-04 US disclosed
EP-0138403-A2 Process for preparing phosphinic acid intermediates E.R. Squibb &amp; Sons, Inc. (US) 1985-04-24 EP disclosed
US-4503064-A BACTERICIDAL ANTIBIOTICS SCHERING CORPORATION (US) 1985-03-05 US disclosed
EP-0110280-A1 Process for the production of penem compounds SCHERING CORPORATION (US) 1984-06-13 EP disclosed
US-4328352-A Process for making norpatchoulenol and novel intermediates useful therein GIVAUDAN CORPORATION (US) 1982-05-04 US disclosed
US-4277631-A Process for making norpatchoulenol GIVAUDAN CORPORATION (US) 1981-07-07 US disclosed
EP-0008663-B1 METHANONAPHTHALENE, AS WELL AS A PROCESS FOR ITS PREPARATION AND ITS USE FOR THE PREPARATION OF NORPATCHOULENOL L. Givaudan & Cie Société Anonyme (CH) 1981-05-20 EP disclosed
EP-0008663-A1 Methanonaphthalene, as well as a process for its preparation and its use for the preparation of norpatchoulenol L. Givaudan & Cie Société Anonyme (CH) 1980-03-19 EP disclosed
US-4072710-A FROM SILYL ESTER AND THIONYL CHLORIDE PALOMO COLL A L 1978-02-07 US disclosed