Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL448939 | 0.86 | MME (0.48) | MMEPPARGPPARDPPARALMNA | |
| SCHEMBL449478 | 0.81 | LMNA (0.43) | MMEPPARGPPARDPPARALMNA | |
| SCHEMBL12492687 | 0.76 | BLM (0.46) | MMEPPARDPPARALMNAKMT2A | |
| SCHEMBL5149405 | 0.76 | BLM (0.46) | MMEPPARDPPARALMNAKMT2A | |
| SCHEMBL2175094 | 0.74 | BLM (0.44) | MMEPPARDPPARALMNAKMT2A | |
| SCHEMBL2175090 | 0.74 | BLM (0.44) | MMEPPARDPPARALMNAKMT2A | |
| SCHEMBL446077 | 0.73 | LMNA (0.42) | MMELMNAKMT2AMMP1MMP9 | |
| SCHEMBL3099777 | 0.73 | LMNA (0.45) | MMELMNAKMT2APOLBCTDSP1 | |
| SCHEMBL12530276 | 0.73 | BLM (0.71) | MMEPPARDPPARALMNAKMT2A | |
| SCHEMBL446707 | 0.73 | TBXA2R (0.44) | MMELMNAKMT2APOLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. | 2012-03-15 | — | — | US | disclosed |
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| US-4800212-A | Pyrrolidone-2 compounds and anti-hypertensive use thereof | BEECHAM GROUP P.L.C. (GB) | 1989-01-24 | — | — | US | disclosed |
| EP-0168619-B1 | N-ACYLATED DI- OR TETRAHYDRONAPHTHALENAMINES, AND ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1988-08-24 | — | — | EP | disclosed |
| EP-0168619-A1 | N-acylated di- or tetrahydronaphthalenamines, and antihypertensive compositions containing them | BEECHAM GROUP PLC (GB) | 1986-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | APP, BACE1, PSEN1 | MME 50/4885PPARG 2403/4885PPARD 2405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.