Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446077 | 0.89 | LMNA (0.42) | LMNAMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL2173983 | 0.83 | KMT2A (0.49) | LMNAMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL449755 | 0.81 | MME (0.48) | LMNAKMT2AMMEALDH1A1SMN1; SMN2 | |
| SCHEMBL7362869 | 0.80 | MMP8 (0.59) | LMNAMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL29256550 | 0.77 | MMP8 (0.52) | LMNAMAPTKMT2AMEN1MMP8 | |
| SCHEMBL29277095 | 0.77 | ALDH1A1 (0.48) | LMNAMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL9395117 | 0.77 | ALDH1A1 (0.55) | LMNAMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL6974147 | 0.76 | MMP8 (0.48) | LMNAMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL5205923 | 0.76 | MMP8 (0.48) | LMNAMAPTMAPK1NPSR1KMT2A | |
| SCHEMBL5205928 | 0.76 | MMP8 (0.48) | LMNAMAPTMAPK1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. | 2012-03-15 | — | — | US | disclosed |
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| US-4800212-A | Pyrrolidone-2 compounds and anti-hypertensive use thereof | BEECHAM GROUP P.L.C. (GB) | 1989-01-24 | — | — | US | disclosed |
| EP-0168619-B1 | N-ACYLATED DI- OR TETRAHYDRONAPHTHALENAMINES, AND ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1988-08-24 | — | — | EP | disclosed |
| EP-0168619-A1 | N-acylated di- or tetrahydronaphthalenamines, and antihypertensive compositions containing them | BEECHAM GROUP PLC (GB) | 1986-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065195-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | APP, BACE1, PSEN1 | LMNA 463/4885MAPT 14/4885MAPK1 1699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.