Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494338 | 1.00 | MAPK1 (0.42) | MAPK1F10ACHEBCHEHRH3 | |
| SCHEMBL4505924 | 0.97 | ACHE (0.42) | MAPK1F10ACHEBCHERORC | |
| SCHEMBL4505927 | 0.97 | ACHE (0.42) | MAPK1F10ACHEBCHERORC | |
| SCHEMBL4488468 | 0.94 | RORC (0.41) | MAPK1F10ACHEBCHEKDR | |
| SCHEMBL4488474 | 0.94 | RORC (0.41) | MAPK1F10ACHEBCHEKDR | |
| SCHEMBL4489331 | 0.93 | CES1 (0.38) | KDRKDM4EALDH1A1MAPTTMEM97 | |
| SCHEMBL4489328 | 0.93 | CES1 (0.38) | KDRKDM4EALDH1A1MAPTTMEM97 | |
| SCHEMBL4477743 | 0.93 | RORC (0.43) | MAPK1RORCTMEM97SIGMAR1CES1 | |
| SCHEMBL4477744 | 0.93 | RORC (0.43) | MAPK1RORCTMEM97SIGMAR1CES1 | |
| SCHEMBL4482774 | 0.91 | KDR (0.39) | KDRPRKAA2PRKAA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689383-A4 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1689383-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051298-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2005-06-09 | — | — | WO | disclosed |