Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1085842 | 0.89 | CYP2D6 (0.48) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1085778 | 0.89 | CYP3A4 (0.48) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL6619301 | 0.84 | CNR1 (0.42) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1086268 | 0.81 | CYP3A4 (0.49) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1086352 | 0.80 | HSD11B1 (0.44) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1086337 | 0.80 | CYP3A4 (0.48) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL6618870 | 0.80 | CNR1 (0.42) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1086154 | 0.80 | FKBP1A (0.51) | CYP3A4ALDH1A1CYP2C9TSHRMEN1 | |
| SCHEMBL1087047 | 0.79 | CYP3A4 (0.48) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL1086441 | 0.79 | HRH3 (0.45) | CYP2D6CYP3A4CYP2C19ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105290-A1 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-Compounds and the Use Thereof for Producing Drugs | GRUENENTHAL GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105290-A1 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-Compounds and the Use Thereof for Producing Drugs | DDO, DAO, OTC | CYP2D6 42/4885CYP3A4 60/4885CYP2C19 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.