Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.59 |
| ▸ | GSK3A | P49840 | 4/20 | 0.59 |
| ▸ | CDK2 | P24941 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | WNT1 | P04628 | 4/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495432 | 0.91 | CHEK1 (0.57) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4491062 | 0.86 | GSK3B (0.55) | GSK3BGSK3ACDK2WNT1DYRK1A | |
| SCHEMBL4505822 | 0.83 | GSK3B (0.66) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4486330 | 0.83 | GSK3B (0.75) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4490154 | 0.83 | MEN1 (0.50) | GSK3BGSK3AWNT1DYRK1AMEN1 | |
| SCHEMBL4486921 | 0.83 | HDAC6 (0.55) | GSK3BHDAC1HDAC2HDAC8POLB | |
| SCHEMBL4500034 | 0.83 | GSK3B (0.58) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4490556 | 0.83 | GSK3B (0.54) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4559036 | 0.82 | GSK3B (0.67) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4503229 | 0.82 | GSK3B (0.64) | GSK3BGSK3ACDK2CYP1A2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |