Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | WNT1 | P04628 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491062 | 0.92 | GSK3B (0.55) | MEN1KMT2AWNT1DYRK1AGSK3B | |
| SCHEMBL4486019 | 0.91 | WNT1 (0.51) | WNT1DYRK1AGSK3BAAK1GSK3A | |
| SCHEMBL4486691 | 0.88 | AAK1 (0.61) | MEN1KMT2AWNT1DYRK1AGSK3B | |
| SCHEMBL4501959 | 0.88 | FGFR1 (0.59) | WNT1DYRK1AFGFR1HDAC6 | |
| SCHEMBL4486921 | 0.85 | HDAC6 (0.55) | GSK3BPOLBFGFR1HDAC6 | |
| SCHEMBL4480187 | 0.84 | GSK3B (0.59) | GSK3BFGFR1HDAC6 | |
| SCHEMBL4488734 | 0.83 | GSK3B (0.53) | GSK3BAAK1GSK3AFGFR1HDAC6 | |
| SCHEMBL4494624 | 0.83 | GSK3B (0.53) | GSK3BAAK1GSK3AFGFR1HDAC6 | |
| SCHEMBL4498353 | 0.83 | GSK3B (0.59) | MEN1KMT2AWNT1DYRK1AGSK3B | |
| SCHEMBL4480802 | 0.83 | CHRM3 (0.47) | GSK3BAAK1GSK3AFGFR1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |