SCHEMBL4516952

SCHEMBL4516952

CCOc1ccc(N2CCN(Cc3nc(-c4ccc(C(F)(F)F)cc4)sc3CCC(=O)c3ccc(O)c(C)c3)CC2)cc1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CETP P11597 3/20 0.43
PPARD Q03181 9/20 0.41
PPARA Q07869 7/20 0.41
PPARG P37231 4/20 0.41
MAPT P10636 4/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
HSP90AA1 P07900 1/20 0.39
CRHBP P24387 1/20 0.39
KMT2A Q03164 1/20 0.39
CRHR2 Q13324 1/20 0.39
FFAR1 O14842 2/20 0.39
TP53 P04637 2/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
BTK Q06187 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4498481 0.94 POLB (0.44) CETPPPARDPPARAPPARGMAPT
SCHEMBL4515600 0.93 CETP (0.46) CETPPPARDPPARAPPARGMAPT
SCHEMBL4522410 0.92 PPARD (0.44) CETPPPARDPPARAPPARGMAPT
SCHEMBL4521400 0.91 CETP (0.44) CETPPPARDPPARAMAPTLMNA
SCHEMBL4517041 0.91 CETP (0.41) CETPPPARDPPARAPPARGMAPT
SCHEMBL4501707 0.91 CETP (0.44) CETPPPARDPPARAMAPTTP53
SCHEMBL4522726 0.89 PPARD (0.56) CETPPPARDPPARAPPARG
SCHEMBL4511561 0.89 CETP (0.43) CETPPPARDPPARAPPARGMAPT
SCHEMBL4515584 0.88 PPARD (0.48) CETPPPARDPPARAPPARGBTK
SCHEMBL4523286 0.88 CACNA1G (0.42) CETPMAPTKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor NIPPON CHEMIPHAR CO., LTD. (JP) 2009-08-13 US disclosed
EP-1897872-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2008-03-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor PPARA, PPARG, PPARD CETP 1172/4885PPARD 3/4885PPARA 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.