Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169393 | 0.81 | ALDH1A1 (0.42) | GPR119TDP1GAALMNAKMT2A | |
| SCHEMBL22898114 | 0.78 | ALDH1A1 (0.44) | CYP2D6POLBALDH1A1TP53CYP3A4 | |
| SCHEMBL24791075 | 0.78 | FFAR4 (0.38) | TDP1GAACYP2D6KMT2AMGAM | |
| SCHEMBL6269261 | 0.77 | MGAM (0.40) | TDP1GAACYP2D6KMT2AJAK2 | |
| SCHEMBL14470714 | 0.76 | HSD17B1 (0.32) | GAAKCNH2GRIN2BPOLB | |
| SCHEMBL1439129 | 0.76 | TDP1 (0.48) | TDP1GAACYP2D6KMT2AMGAM | |
| SCHEMBL1881523 | 0.76 | ALDH1A1 (0.46) | TDP1GAAKMT2AMGAMSI | |
| SCHEMBL2721040 | 0.76 | — | — | |
| SCHEMBL16908082 | 0.76 | ALDH1A1 (0.42) | GPR119CYP2D6KMT2APOLBALDH1A1 | |
| SCHEMBL3311175 | 0.76 | TDP1 (0.37) | TDP1GAACYP2D6KMT2AMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024356-A1 | BICYCLIC DERIVATIVES AS CETP INHIBITORS | Novartis AG (CH) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007128568-A1 | BICYCLIC DERIVATIVES AS CETP INHIBITORS | NOVARTIS AG (CH) | 2007-11-15 | — | — | WO | disclosed |