Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | FPR2 | P25090 | 5/20 | 0.35 |
| ▸ | FPR1 | P21462 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639132 | 0.81 | TSHR (0.40) | ALDH1A1TSHRMMEACEMAPT | |
| SCHEMBL2464736 | 0.77 | NAMPT (0.43) | KDM4EFPR2FPR1ALDH1A1MME | |
| SCHEMBL5640152 | 0.76 | F2 (0.42) | F10 | |
| SCHEMBL6224270 | 0.76 | LMNA (0.42) | LMNA | |
| SCHEMBL5638887 | 0.75 | EPHX2 (0.46) | ALDH1A1 | |
| SCHEMBL318740 | 0.73 | INMT (0.42) | MMEACEF10 | |
| SCHEMBL318806 | 0.73 | XIAP (0.40) | KDM4EMMEACEMAPTF10 | |
| SCHEMBL319191 | 0.73 | XIAP (0.40) | KDM4EMMEACEMAPTF10 | |
| SCHEMBL318738 | 0.73 | INMT (0.42) | MMEACEF10 | |
| SCHEMBL5639144 | 0.72 | NAMPT (0.47) | TSHRMMEACEF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029581-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007126871-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-11-08 | — | — | WO | disclosed |