Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.81 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.52 |
| ▸ | HTT | P42858 | 6/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063275 | 0.98 | LMNA (0.85) | LMNADNM1HTTHSP90AA1RAD52 | |
| Bromide SCHEMBL1494723 | 0.92 | LMNA (0.96) | LMNADNM1HTTHSP90AA1RAD52 | |
| Bromide SCHEMBL29712384 | 0.92 | LMNA (0.96) | LMNADNM1HTTHSP90AA1RAD52 | |
| Bromide SCHEMBL2158161 | 0.92 | LMNA (0.96) | LMNADNM1HTTHSP90AA1RAD52 | |
| Bromide SCHEMBL28430194 | 0.92 | LMNA (0.96) | LMNADNM1HTTHSP90AA1RAD52 | |
| Bromide SCHEMBL29706404 | 0.92 | LMNA (0.96) | LMNADNM1HTTHSP90AA1RAD52 | |
| Bromide SCHEMBL28429574 | 0.92 | LMNA (0.96) | LMNADNM1HTTHSP90AA1RAD52 | |
| SCHEMBL18335570 | 0.90 | LMNA (0.73) | LMNADNM1HTTHSP90AA1RAD52 | |
| SCHEMBL13388580 | 0.90 | LMNA (1.00) | LMNADNM1HTTHSP90AA1RAD52 | |
| SCHEMBL31255930 | 0.90 | LMNA (1.00) | LMNADNM1HTTHSP90AA1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069229-A1 | METHOD FOR NANOPARTICLE SURFACE MODIFICATION | 3M Innovative Properties Company (US) | 2009-06-17 | — | — | EP | disclosed |
| US-20080069887-A1 | Method for nanoparticle surface modification | 3M INNOVATIVE PROPERTIES COMPANY | 2008-03-20 | — | — | US | disclosed |
| WO-2008033718-A1 | METHOD FOR NANOPARTICLE SURFACE MODIFICATION | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080069887-A1 | Method for nanoparticle surface modification | MGMT, AS3MT, NCL | LMNA 2919/4885DNM1 2156/4885HTT 1919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.