Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8817995 | 0.85 | TSHR (0.57) | TSHRALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL9592732 | 0.81 | TSHR (0.49) | TSHRALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL326537 | 0.78 | CYP1A2 (0.41) | TSHRALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL28160183 | 0.76 | ALDH1A1 (0.44) | TSHRALDH1A1HPGDMAPTLMNA | |
| SCHEMBL27830335 | 0.75 | TSHR (0.53) | TSHRALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL27558949 | 0.75 | ALDH1A1 (0.48) | TSHRALDH1A1HPGDMAPTLMNA | |
| SCHEMBL3112611 | 0.75 | NOTUM (0.40) | ALDH1A1HPGDMAPTLMNACYP2C19 | |
| SCHEMBL8327982 | 0.75 | TSHR (0.49) | TSHRALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL3389839 | 0.74 | ALDH1A1 (0.52) | TSHRALDH1A1HPGDMAPTLMNA | |
| SCHEMBL16289708 | 0.73 | TSHR (0.59) | TSHRALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585883-B2 | Substituted pyridines and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| EP-1817303-A2 | SUBSTITUTED PYRIDINES WITH ACTIVITY ON SYK KINASE | Rigel Pharmaceuticals, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| US-20060178407-A1 | Substituted pyridines and their uses | RIGEL PHARMACEUTICAL, INC. (US) | 2006-08-10 | — | — | US | disclosed |
| WO-2006050480-A2 | SUBSTITUTED PYRIDINES WITH ACTIVITY ON SYK KINASE | RIGEL PHARMACEUTICALS, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178407-A1 | Substituted pyridines and their uses | KIT, CPA3, CMA1 | TSHR 4213/4885ALDH1A1 613/4885MEN1 2848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.