Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29560985 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| SCHEMBL1314802 | 0.87 | HTT (0.43) | SMN1; SMN2HTTLMNAKMT2AMEN1 | |
| SCHEMBL501235 | 0.86 | RECQL (0.45) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL502252 | 0.85 | HTT (0.42) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| SCHEMBL9608992 | 0.84 | NPC1 (0.39) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| SCHEMBL29714427 | 0.82 | LOX (0.45) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| SCHEMBL19755849 | 0.82 | LOX (0.45) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| SCHEMBL6931382 | 0.82 | HTT (0.37) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| SCHEMBL5898063 | 0.82 | HTT (0.41) | SMN1; SMN2HTTLMNAALDH1A1MAPK1 | |
| SCHEMBL190086 | 0.82 | RECQL (0.41) | SMN1; SMN2HTTALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334721-B1 | CGRP RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3341370-B1 | CGRP RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2021-04-28 | — | — | EP | disclosed |
| CN-107922385-B | CGRP receptor antagonists | 伊莱利利公司 | 2020-09-08 | — | — | CN | disclosed |
| CN-107922406-B | CGRP receptor antagonists | 伊兰科美国公司 | 2020-04-03 | — | — | CN | disclosed |
| EP-3341370-A1 | CGRP RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2018-07-04 | — | — | EP | disclosed |
| CN-105283453-B | N- (pyridin-2-yl) pyrimidin-4-amine derivatives containing sulfone group | 拜耳药业股份公司 | 2018-06-22 | — | — | CN | disclosed |
| EP-3334721-A1 | CGRP RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2018-06-20 | — | — | EP | disclosed |
| CN-107922385-A | Cgrp receptor antagonists | 伊莱利利公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107922406-A | CGRP receptor antagonist | 伊莱利利公司 | 2018-04-17 | — | — | CN | disclosed |
| US-9877954-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | disclosed |
| US-5298507-A | Insecticides | NIHON BAYER AGROCHEM K.K. (JP) | 1994-03-29 | — | — | US | disclosed |
| US-5204360-A | Insecticides | NIHON BAYER AGROCHEM K.K. (JP) | 1993-04-20 | — | — | US | disclosed |
| US-5001138-A | Insecticides | NIHON TOKUSHU NOYAKU SEIZO, K.K. (JP) | 1991-03-19 | — | — | US | disclosed |
| US-4845106-A | INSECTICIDES | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1989-07-04 | — | — | US | disclosed |
| US-4812571-A | NITROMETHYLENE COMPOUNDS | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1989-03-14 | — | — | US | disclosed |
| US-4774247-A | Nitromethylene derivative insecticides | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1988-09-27 | — | — | US | disclosed |
| US-4742060-A | 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES | NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) | 1988-05-03 | — | — | US | disclosed |
| US-4678795-A | 1-pyridylmethyl-2-nitromethylene-1,3-diazacycloalkane insecticides | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1987-07-07 | — | — | US | disclosed |
| EP-0192060-A1 | Heterocyclic compounds | NIHON BAYER AGROCHEM K.K. (JP) | 1986-08-27 | — | — | EP | disclosed |
| EP-0163855-A1 | Nitromethylene derivatives, intermediates, and process for their preparation as insecticides | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1985-12-11 | — | — | EP | disclosed |