Sugi Predict

Sugi Predict / Compounds / SCHEMBL190086

SCHEMBL190086

SCHEMBL190086

ClCc1cc(Cl)nc(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RECQL P46063 1/20 0.41
▸ S1PR2 O95136 1/20 0.37
▸ LOX P28300 1/20 0.36
▸ LOXL3 P58215 1/20 0.36
▸ LOXL2 Q9Y4K0 1/20 0.36
▸ HSP90AB1 P08238 1/20 0.34
▸ KDM4E B2RXH2 2/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ HIF1A Q16665 1/20 0.33
▸ FFAR1 O14842 1/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ HTT P42858 2/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.31
▸ TACR1 P25103 1/20 0.31
▸ SLC6A4 P31645 1/20 0.31
▸ KCNH2 Q12809 1/20 0.31
▸ GFER P55789 1/20 0.30
▸ GRM5 P41594 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6869464 0.97 RECQL (0.39) RECQLS1PR2LOXLOXL3LOXL2
SCHEMBL904515 0.82 RECQL (0.54) RECQLS1PR2LOXLOXL3LOXL2
SCHEMBL4501039 0.82 SMN1; SMN2 (0.44) RECQLKDM4ECYP3A4CYP2C19HIF1A
SCHEMBL29560985 0.82 SMN1; SMN2 (0.44) RECQLKDM4ECYP3A4CYP2C19HIF1A
SCHEMBL2056128 0.77 SMN1; SMN2 (0.42) RECQLS1PR2LOXLOXL3LOXL2
SCHEMBL855313 0.77 LOXL2 (0.54) RECQLS1PR2LOXLOXL3LOXL2
SCHEMBL18738971 0.77 IDO1 (0.42) RECQLS1PR2LOXLOXL3LOXL2
SCHEMBL5898392 0.77 S1PR2 (0.39) RECQLS1PR2LOXLOXL3LOXL2
SCHEMBL6002612 0.77 S1PR2 (0.39) RECQLS1PR2LOXLOXL3LOXL2
SCHEMBL1633598 0.77 S1PR2 (0.34) RECQLS1PR2LOXLOXL3LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220306623-A1 PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2022-09-29 — — US disclosed
EP-3983409-A1 PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS GlaxoSmithKline Intellectual Property Development Limited (GB) 2022-04-20 — — EP disclosed
US-11254671-B2 Chemical compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2022-02-22 — — US disclosed
US-11254671-B2 Chemical compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2022-02-22 — — US disclosed
CN-114008044-A Pyridyl or pyrimidinyl MTOR kinase inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2022-02-01 — — CN disclosed
US-20210163472-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2021-06-03 — — US disclosed
US-20210163472-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2021-06-03 — — US disclosed
WO-2020249652-A1 PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-12-17 — — WO disclosed
EP-3724187-A1 6-(MORPHOLIN-4-YL)-PYRIDIN-2-YL-1H-PYRROLO[3,2-B]PYRIDINE DERIVATIVES AS M-TOR INHIBITORS GlaxoSmithKline Intellectual Property Development Limited (GB) 2020-10-21 — — EP disclosed
CN-111491932-A 6- (morpholin-4-yl) -pyridin-2-yl-1H-pyrrolo [3,2-B ] pyridine derivatives as M-TOR inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2020-08-04 — — CN disclosed
US-5049569-A Acylated ureas CIBA-GEIGY CORPORATION (US) 1991-09-17 — — US disclosed
US-5001138-A Insecticides NIHON TOKUSHU NOYAKU SEIZO, K.K. (JP) 1991-03-19 — — US disclosed
US-4968344-A FUNGICIDES, BACTERICIDES CIBA-GEIGY CORPORATION (US) 1990-11-06 — — US disclosed
US-4845106-A INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-07-04 — — US disclosed
US-4812571-A NITROMETHYLENE COMPOUNDS NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-03-14 — — US disclosed
US-4774247-A Nitromethylene derivative insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1988-09-27 — — US disclosed
US-4742060-A 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) 1988-05-03 — — US disclosed
US-4678795-A 1-pyridylmethyl-2-nitromethylene-1,3-diazacycloalkane insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1987-07-07 — — US disclosed
EP-0192060-A1 Heterocyclic compounds NIHON BAYER AGROCHEM K.K. (JP) 1986-08-27 — — EP disclosed
EP-0163855-A1 Nitromethylene derivatives, intermediates, and process for their preparation as insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1985-12-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210163472-A1 CHEMICAL COMPOUNDS MTOR, RICTOR, RPTOR RECQL 2359/4885S1PR2 474/4885LOX 2896/4885
US-11254671-B2 Chemical compounds MTOR, RICTOR, RPTOR RECQL 2359/4885S1PR2 474/4885LOX 2896/4885
US-20220306623-A1 PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS MTOR, RICTOR, RPTOR RECQL 984/4885S1PR2 408/4885LOX 3290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.