Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.70 |
| ▸ | KDR | P35968 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.58 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.58 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | GCGR | P47871 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545944 | 0.83 | BRAF (0.53) | MCHR1KDRNPC1RAB9AKMT2A | |
| SCHEMBL4968829 | 0.81 | GCGR (0.69) | MCHR1KDRNPC1RAB9AKMT2A | |
| SCHEMBL4491205 | 0.80 | HRH3 (0.60) | MCHR1KDRNPC1RAB9AKMT2A | |
| SCHEMBL12128447 | 0.78 | HRH4 (0.72) | MCHR1KDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30186207 | 0.78 | HRH3 (0.81) | HRH3LTA4H | |
| SCHEMBL11151279 | 0.78 | HRH3 (0.81) | HRH3LTA4H | |
| SCHEMBL14385803 | 0.77 | HRH3 (0.55) | MCHR1KDRKDM4EHRH3PSMB1 | |
| SCHEMBL5176439 | 0.77 | KDR (0.65) | KDRHRH3PSMB1PSMB5LTA4H | |
| SCHEMBL13202486 | 0.77 | HRH3 (0.58) | MCHR1KDRKDM4EHRH3 | |
| SCHEMBL2112484 | 0.77 | ESR1 (0.61) | PSMB1PSMB5PSMB2LTA4HGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954670-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062230-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX, INC. (US) | 2007-05-31 | — | — | WO | disclosed |