Sugi Predict

Sugi Predict / Compounds / SCHEMBL4502873

SCHEMBL4502873

SCHEMBL4502873

Nc1n[nH]c2cc(Cl)ccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDPK1 O15530 10/20 0.60
▸ JAK2 O60674 4/20 0.60
▸ KDM4E B2RXH2 1/20 0.52
▸ CYP3A4 P08684 1/20 0.52
▸ GAA P10253 1/20 0.52
▸ SGK1 O00141 3/20 0.50
▸ MAP2K4 P45985 2/20 0.49
▸ TRPA1 O75762 1/20 0.47
▸ AURKA O14965 2/20 0.46
▸ TGFBR1 P36897 2/20 0.46
▸ ROCK1 Q13464 2/20 0.46
▸ AURKB Q96GD4 2/20 0.46
▸ CHUK O15111 1/20 0.46
▸ RPS6KB1 P23443 1/20 0.46
▸ CDK2 P24941 1/20 0.46
▸ KDR P35968 1/20 0.46
▸ SYK P43405 1/20 0.46
▸ JAK3 P52333 1/20 0.46
▸ MAP3K5 Q99683 1/20 0.46
▸ CHEK1 O14757 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6488855 0.85 JAK2 (0.72) PDPK1JAK2SGK1AURKATGFBR1
SCHEMBL482445 0.83 JAK2 (0.67) PDPK1JAK2KDM4ECYP3A4GAA
SCHEMBL14738828 0.81 MAP2K4 (0.63) PDPK1MAP2K4TRPA1CHEK1GSK3B
SCHEMBL3593032 0.81 MAP2K4 (0.50) JAK2MAP2K4TRPA1CHEK1GSK3B
SCHEMBL4494112 0.81 JAK2 (0.77) PDPK1JAK2SGK1AURKATGFBR1
SCHEMBL6489879 0.80 JAK2 (0.65) PDPK1JAK2SGK1AURKATGFBR1
SCHEMBL922069 0.78 PDPK1 (0.65) PDPK1JAK2KDM4ECYP3A4GAA
SCHEMBL15529807 0.78 GSK3B (0.48) PDPK1JAK2MAP2K4TRPA1CHEK1
SCHEMBL1553907 0.78 MAP2K4 (0.47) MAP2K4TRPA1CHEK1GSK3B
SCHEMBL3155790 0.78 CHEK1 (0.50) CYP3A4MAP2K4TRPA1CDK2CHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080001-A Perfluoroalkyl substituted pyrimido [1,2-b ] indazole ketone compound and preparation method thereof — 2026-05-26 — — CN claimed
CN-101962365-A Aminoindazole derivatives as protein-kinase inhibitors AVENTIS PHARMA SA 2011-02-02 — — CN claimed
CN-1656078-A Aminoindazole derivatives as protein kinase inhibitors AVENTIS PHARMA SA (FR) 2005-08-17 — — CN claimed
US-20040014802-A1 Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof AVENTIS PHARMA S.A. (FR) 2004-01-22 — — US claimed
US-RE28939-E MUSCLE RELAXANTS, ANALGESICS SMITHKLINE CORPORATION (US) 1976-08-24 — — US claimed
CN-122080001-A Perfluoroalkyl substituted pyrimido [1,2-b ] indazole ketone compound and preparation method thereof — 2026-05-26 — — CN disclosed
WO-2024178219-A1 1-ACYL-3-AMINOINDAZOLES FOR TREATING CYSTIC FIBROSIS SHOICHET BRIAN (US) 2024-08-29 — — WO disclosed
US-12065430-B2 Indazole compound or salt thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2024-08-20 — — US disclosed
EP-3871673-B1 NOVEL INDAZOLE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO LTD (JP) 2024-01-03 — — EP disclosed
US-20230181536-A1 ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C TAIHO PHARMACEUTICAL CO LTD (JP) 2023-06-15 — — US disclosed
CN-110818683-B 2-pyridine substituted urea structure small molecule compound and synthesis and application thereof 中国科学院上海药物研究所 2023-04-14 — — CN disclosed
US-20210395234-A1 NOVEL INDAZOLE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO. LTD. (JP) 2021-12-23 — — US disclosed
EP-0090972-A2 Indazole derivatives Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1983-10-12 — — EP disclosed
US-4218369-A FOR DYEING POLYACRYLONITRILE PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1980-08-19 — — US disclosed
US-4084053-A YELLOW AND ORANGE DYES, PYRIMIDINO(4',5':5,6)-1,2,4-TRIAZINO(4,3-BETA)INDAZOLES CIBA-GEIGY CORPORATION (US) 1978-04-11 — — US disclosed
US-4065568-A 3-Carbo(lower alkoxy)hydrazinoindazoles BAYER AKTIENGESELLSCHAFT (DT) 1977-12-27 — — US disclosed
US-4051252-A ANALGESIC, ANTIINFLAMMATORY, ANTIPYRETIC BAYER AKTIENGESELLSCHAFT (DT) 1977-09-27 — — US disclosed
US-4017479-A Cationic indazole-azo-5-amino pyrazole dyestuffs CIBA-GEIGY AG (CH) 1977-04-12 — — US disclosed
US-4001203-A Heavy metal complexes of azo dyestuffs containing a heterocyclic diazo component and the residue of 5-halogeno-2,3-dihydrozypyridine as coupling component CIBA-GEIGY AG (CH) 1977-01-04 — — US disclosed
US-RE28939-E MUSCLE RELAXANTS, ANALGESICS SMITHKLINE CORPORATION (US) 1976-08-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014802-A1 Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof CYP2C8, NR0B2, NR2C2 PDPK1 4495/4885JAK2 1774/4885KDM4E 3563/4885
US-12065430-B2 Indazole compound or salt thereof RCOR3, H1-3, BICRA PDPK1 2706/4885JAK2 12/4885KDM4E 3013/4885
US-20230181536-A1 ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C KRAS, NRAS, HRAS PDPK1 1382/4885JAK2 122/4885KDM4E 3461/4885
US-20210395234-A1 NOVEL INDAZOLE COMPOUND OR SALT THEREOF HDAC11, RCOR3, BICRA PDPK1 2291/4885JAK2 16/4885KDM4E 2504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.