Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6550868 | 0.98 | USP2 (0.72) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL11791414 | 0.88 | USP2 (0.57) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL709506 | 0.86 | USP2 (1.00) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL8391173 | 0.84 | MEN1 (0.52) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL9819626 | 0.84 | MEN1 (0.52) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL4384137 | 0.80 | USP2 (0.78) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL11186 | 0.80 | USP2 (0.78) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL4388837 | 0.80 | USP2 (0.78) | USP2ATMTSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL22470454 | 0.79 | USP2 (0.56) | USP2ATMTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL488808 | 0.79 | MEN1 (0.68) | USP2ATMTSHRSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179910-B2 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | claimed |
| US-11186583-B2 | 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2021-11-30 | — | — | US | disclosed |
| EP-3749670-B1 | 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA | UNIV PALACKEHO (CZ) | 2021-10-06 | — | — | EP | disclosed |
| US-10889748-B2 | Process for preparing dibenzylamine quaternary ammonium salt high-temperature resistant corrosion inhibitor and applications thereof | SOUTHWEST PETROLEUM UNIVERSITY (CN) | 2021-01-12 | — | — | US | disclosed |
| US-20200361943-A1 | 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2020-11-19 | — | — | US | disclosed |
| US-20200339865-A1 | PROCESS FOR PREPARING DIBENZYLAMINE QUATERNARY AMMONIUM SALT HIGH-TEMPERATURE RESISTANT CORROSION INHIBITOR AND APPLICATIONS THEREOF | SOUTHWEST PETROLEUM UNIVERSITY (CN) | 2020-10-29 | — | — | US | disclosed |
| CN-111499596-A | Preparation method of furaltadone hydrochloride | 衢州伟荣药化有限公司 | 2020-08-07 | — | — | CN | disclosed |
| WO-2020082476-A1 | PREPARATION METHOD FOR AND USE OF DIBENZYLAMINE QUATERNARY AMMONIUM SALT HIGH-TEMPERATURE RESISTANT ACIDIZING CORROSION INHIBITOR | 西南石油大学 | 2020-04-30 | — | — | WO | disclosed |
| US-8513221-B2 | PI3K isoform selective inhibitors | Xcovery Holding, LLC (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513221-B2 | PI3K isoform selective inhibitors | Xcovery Holding, LLC (US) | 2013-08-20 | — | — | US | disclosed |
| EP-1370554-A1 | 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2003-12-17 | — | — | EP | disclosed |
| US-6653308-B2 | Anticancer agents; antidiabetic agents; antiinflammatory agents | SUGEN, INC. | 2003-11-25 | — | — | US | disclosed |
| US-20030130280-A1 | Treatment of acute myeloid leukemia with indolinone compounds | SUGEN, INC. | 2003-07-10 | — | — | US | disclosed |
| US-20030092917-A1 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors | SUGEN, INC. | 2003-05-15 | — | — | US | disclosed |
| WO-2003035009-A2 | TREATMENT OF ACUTE MYELOID LEUKEMIA WITH INDOLINONE COMPOUNDS | SUGEN, INC. (US) | 2003-05-01 | — | — | WO | disclosed |
| WO-2002066463-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2002-08-29 | — | — | WO | disclosed |
| US-5773437-A | UROGENITAL DISORDERS SUCH AS DYSURIA | NIPPON CHEMIPHAR CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| CN-1148853-A | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1997-04-30 | — | — | CN | disclosed |
| EP-0753514-A1 | ALKYLENEDIAMINE DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1997-01-15 | — | — | EP | disclosed |
| EP-0486211-A1 | Isoquinoline derivatives | CHINOIN Gyògyszer és Vegyészeti Termékek Gyára RT. (HU) | 1992-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339865-A1 | PROCESS FOR PREPARING DIBENZYLAMINE QUATERNARY AMMONIUM SALT HIGH-TEMPERATURE RESISTANT CORROSION INHIBITOR AND APPLICATIONS THEREOF | ABL1, TYR, KCNN1 | USP2 1781/4885ATM 946/4885TSHR 4427/4885 |
| US-10889748-B2 | Process for preparing dibenzylamine quaternary ammonium salt high-temperature resistant corrosion inhibitor and applications thereof | ABL1, TYR, KCNN1 | USP2 1781/4885ATM 946/4885TSHR 4427/4885 |
| US-20200361943-A1 | 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA | TK1, DCK, CCNK | USP2 2898/4885ATM 289/4885TSHR 3045/4885 |
| US-20030130280-A1 | Treatment of acute myeloid leukemia with indolinone compounds | FLT3, FLI1, MCL1 | USP2 4376/4885ATM 108/4885TSHR 2959/4885 |
| US-20030092917-A1 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors | PDPK1, MKNK1, PKN2 | USP2 3652/4885ATM 259/4885TSHR 4437/4885 |
| US-11186583-B2 | 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma | TK1, DCK, CCNK | USP2 2898/4885ATM 289/4885TSHR 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.