Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4475090 | 0.72 | GNRHR (0.53) | GNRHRHTR2A | |
| SCHEMBL4503002 | 0.71 | GNRHR (1.00) | GNRHRDRD2DRD3 | |
| SCHEMBL4499727 | 0.69 | GNRHR (1.00) | GNRHRHTR2ADRD2DRD3 | |
| SCHEMBL4503724 | 0.69 | GNRHR (1.00) | GNRHRHTR2ADRD2DRD3 | |
| SCHEMBL5362589 | 0.68 | SMN1; SMN2 (0.72) | MEN1KMT2AALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL19212301 | 0.68 | L3MBTL1 (0.60) | MEN1KMT2AALDH1A1DRD2DRD3 | |
| SCHEMBL1842426 | 0.68 | MEN1 (0.61) | MEN1KMT2AKDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL12061638 | 0.68 | TGM2 (0.63) | MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL3970912 | 0.68 | MEN1 (0.76) | MEN1KMT2AALDH1A1GRIN2BTSHR | |
| SCHEMBL4814264 | 0.68 | MEN1 (0.76) | MEN1KMT2AALDH1A1GRIN2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582636-B2 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582636-B2 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582636-B2 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20060270848-A1 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270848-A1 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of gonadotropin releasing hormone receptor | GNRHR, PRLHR, FSHR | GNRHR 1/4885MEN1 3337/4885KMT2A 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.